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Leon Solomon Lerman (June 27, 1925 – September 26, 2012) was a distinguished American molecular biologist and geneticist. He is most renowned for his groundbreaking discovery in the early 1960s that certain acridine-based mutagens, such as proflavine, act by intercalating themselves—inserting flatly—between the stacked base pairs of the DNA double helix. This model of intercalation provided crucial insights into DNA structure, its interaction with various molecules, and the mechanisms of mutagenesis. Later in his career, Lerman also pioneered the technique of Denaturing Gradient Gel Electrophoresis (DGGE) in the late 1970s and early 1980s. DGGE is a powerful method for separating DNA fragments based on differences in their melting behavior, which became invaluable for detecting mutations, polymorphisms, and analyzing microbial community diversity. He held positions at several prestigious institutions including the University of Colorado, Vanderbilt University, and the Massachusetts Institute of Technology (MIT).
Leon Lerman's work history includes a series of influential roles in various companies. Here is a detailed list of his professional journey:
In 1961, Lerman published seminal work demonstrating that acridine dyes (like proflavine) bind to DNA by inserting themselves between adjacent base pairs, a process he termed intercalation. This explained their mutagenic properties and significantly advanced the understanding of DNA-ligand interactions.
Invented and developed DGGE in the late 1970s and early 1980s, a technique that allows for the separation of DNA molecules differing by as little as a single base substitution based on their melting properties in a chemical denaturant gradient. This became a key tool in genetics and microbial ecology.
In recognition of his significant contributions to molecular biology and genetics, Leon Lerman was elected as a member of the U.S. National Academy of Sciences in 1981.
Investigated the phenomenon of psi (polymer and salt-induced) condensation of DNA, exploring how long DNA molecules can be tightly packaged into compact structures, relevant to DNA organization in viral capsids and cell nuclei.
The Open University of Israel - Year 2013
Mihlelet ORT Givat Ram - Year 2004
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Cynerio is a healthcare cybersecurity company dedicated to protecting medical devices (IoMT), IoT, and OT systems within hospitals and healthcare facilities. Their platform provides comprehensive visibility into all connected devices, conducts risk assessments, detects anomalous behavior, and enables automated threat prevention and response. This helps healthcare organizations safeguard patient data, ensure patient safety, maintain operational continuity, and comply with industry regulations by securing the ever-expanding network of connected clinical and operational assets against cyber threats like ransomware and data breaches.
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