Leo Coates
Greater Chicago Area,United States
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Dr. Leo Coates is a Distinguished Scientist and group leader at Oak Ridge National Laboratory (ORNL), specializing in structural biology with a strong focus on neutron crystallography. His research is pivotal in understanding complex biological systems at the atomic level, particularly the roles of hydrogen atoms and hydration in protein function and enzyme mechanisms. Dr. Coates leads efforts in developing and applying advanced neutron scattering techniques and instrumentation, such as the MaNDi (Macromolecular Neutron Diffractometer) instrument at the Spallation Neutron Source (SNS). His work significantly contributes to areas like drug discovery, by elucidating how drugs bind to their target proteins, and bioenergy, by investigating enzymes involved in biomass conversion. He is recognized for his expertise in obtaining high-resolution structural information that is often inaccessible by other methods, providing unique insights into protonation states, solvent structures, and dynamic processes in biomolecules.
Professional Summary
Leo Coates's work history includes a series of influential roles in various companies. Here is a detailed list of his professional journey:
Notable Achievements
Fellow of the American Association for the Advancement of Science (AAAS)
Elected as an AAAS Fellow in 2020 for distinguished contributions to the field of structural biology and neutron scattering, particularly for applications in understanding biological mechanisms and for leadership in developing neutron instrumentation.
Leadership in Neutron Science for Biology
Leads the Chemical and Structural Dynamics group in the Biology and Soft Matter Division at ORNL and has been instrumental in establishing and operating world-leading neutron instruments like MaNDi for biological research.
Pioneering Research in Neutron Protein Crystallography
Authored numerous high-impact publications detailing the structures of proteins and enzymes, revealing critical information about hydrogen bonding networks, protonation states of catalytic residues, and drug binding modes, which are vital for understanding biological function and for rational drug design.
Development of Advanced Crystallographic Methods
Contributed to the development of novel experimental and computational methods for neutron crystallography, improving data quality and a_nalysis, and making the technique more accessible for challenging biological systems.
UT-Battelle Awards for Science and Technology
Recipient of multiple UT-Battelle awards recognizing his significant scientific achievements and contributions to ORNL's research mission.
Educational Background
B.A. Communications
Western Sydney University - Year 2003
Cranbrook School - Year 1990
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Company Overview
Coates GroupCoates Group is a global technology company specializing in creating immersive digital experiences for Quick Service Restaurants (QSR) and retail brands. They design and deploy solutions like digital menu boards, self-order kiosks, drive-thru technology, and content management systems (Switchboard CMS) to enhance customer engagement, streamline operations, and drive sales for major international brands.
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