David Liu is a pioneering researcher and innovator in the field of chemical biology and genome editing. He is a core institute member of the Broad Institute, the Richard Merkin Professor and director of the Merkin Institute of Transformative Technologies in Healthcare at the Broad Institute, a professor of chemistry and chemical biology at Harvard University, and a Howard Hughes Medical Institute (HHMI) investigator. His research group integrates chemistry and evolution to illuminate biology and enable next-generation therapeutics. David is widely recognized for his groundbreaking work on base editing and prime editing, revolutionary gene editing technologies that offer new possibilities for treating genetic diseases with unprecedented precision.
David Liu's work history includes a series of influential roles in various companies. Here is a detailed list of his professional journey:
Co-invented base editing, a gene editing technology that enables direct, irreversible conversion of one DNA base pair to another at a target genomic locus without requiring double-strand DNA breaks or donor DNA templates. This has opened new avenues for precise genetic modification and therapeutic development.
Led the development of prime editing, a versatile 'search-and-replace' genome editing technology that can directly write new genetic information into a specified DNA site. Prime editing expands the scope of genome editing by enabling all 12 possible base-to-base conversions, as well as targeted insertions and deletions.
Appointed as a Howard Hughes Medical Institute (HHMI) Investigator, recognizing his significant contributions to biomedical research and his potential for future transformative discoveries.
Recipient of prestigious awards including the NIH Director's Pioneer Award, the ACS Award in Pure Chemistry, the Feynman Prize in Nanotechnology, and election to the National Academy of Sciences and the National Academy of Medicine, underscoring the impact of his research.
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