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Zynerba Pharmaceuticals was a clinical-stage specialty pharmaceutical company dedicated to developing and commercializing innovative transdermally delivered cannabinoid therapeutics for rare and near-rare neuropsychiatric disorders. Their lead product candidate was Zygelâ„¢ (ZYN002), a pharmaceutically-produced cannabidiol (CBD) formulated as a permeation-enhanced gel for transdermal delivery, which was being evaluated for conditions including Fragile X syndrome, 22q11.2 deletion syndrome, and autism spectrum disorder. In October 2023, Zynerba Pharmaceuticals was acquired by Harmony Biosciences.
Prior to its acquisition, this was Zynerba's global headquarters, centralizing R&D leadership, clinical operations management, corporate strategy, and administrative functions.
Located in a suburban office park, the facility provided standard corporate office amenities suitable for a clinical-stage biopharmaceutical company. No unique architectural features are widely publicized.
The work culture at Zynerba's HQ was likely intensive and mission-driven, focused on advancing its novel therapies through rigorous clinical trials, with a strong emphasis on scientific innovation and addressing unmet patient needs in neuropsychiatric disorders.
It was the nerve center for Zynerba's strategic decisions, research direction, clinical development programs, and operational execution during its development of transdermal cannabinoid treatments.
Prior to its acquisition, Zynerba Pharmaceuticals' global presence was primarily defined by its clinical trial activities, which enrolled patients in multiple countries as required by study protocols for its investigational therapies like Zygel. The company was focused on potential U.S. commercialization and exploring ex-U.S. partnerships but did not have established international commercial offices. Its core R&D, clinical, and corporate functions were centralized in its U.S. headquarters.
80 W. Lancaster Avenue, Suite 300
Devon
PA
USA
No additional office locations available.
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As of April 2025, Zynerba Pharmaceuticals' leadership includes:
Zynerba Pharmaceuticals has been backed by several prominent investors over the years, including:
In the 12 months preceding its acquisition by Harmony Biosciences in October 2023, Zynerba Pharmaceuticals experienced key executive team changes. This included the appointment of a new Chief Commercial Officer and the retirement of its President. The acquisition subsequently led to the transition of the entire then-current executive team as Zynerba was integrated into Harmony Biosciences.
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Prior to its acquisition, Zynerba Pharmaceuticals likely utilized standard corporate email address formats. Common patterns for companies of its type include [first_initial][last]@[companydomain].com or [first].[last]@[companydomain].com. For Zynerba, the domain was zynerba.com.
flast@zynerba.com
Format
jdoe@zynerba.com
Example
75%
Success rate
Harmony Biosciences (via Business Wire) • October 17, 2023
Harmony Biosciences Holdings, Inc. announced the successful completion of its tender offer to acquire all outstanding shares of Zynerba Pharmaceuticals, Inc. The acquisition added Zynerba's Zygel (CBD gel) to Harmony's pipeline, aiming to expand its offerings in rare neurological disorders....more
Zynerba Pharmaceuticals Press Release • August 14, 2023
Zynerba Pharmaceuticals announced that it had entered into a definitive agreement to be acquired by Harmony Biosciences. The deal valued Zynerba at approximately $60 million in cash plus contingent value rights....more
Zynerba Pharmaceuticals Press Release • June 26, 2023
Zynerba announced the publication of positive 38-week data from its open-label Phase 2 INSPIRE trial, showing Zygel was well-tolerated and demonstrated improvements in behavioral endpoints in children and adolescents with 22q11.2 Deletion Syndrome....more
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