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Talaris Therapeutics, Inc. was a clinical-stage cell therapy company dedicated to developing FCR001, an innovative allogeneic cell therapy aimed at establishing durable immune tolerance in patients. The company's research primarily targeted organ transplant rejection, severe autoimmune diseases, and certain immune-mediated hematologic conditions. In a significant strategic shift, Talaris Therapeutics completed a reverse merger with Tourmaline Bio, Inc. in October 2023. The merged entity now operates as Tourmaline Bio, concentrating on the development of TOUR006 for thyroid eye disease and atherosclerotic cardiovascular disease.
Served as the primary center for Talaris's executive leadership, corporate strategy, clinical development oversight, financial operations, and administrative functions.
The headquarters was situated in a modern office building within Boston's renowned biopharmaceutical cluster, offering proximity to leading research institutions, collaborators, and a skilled talent pool.
As a clinical-stage biotechnology firm, Talaris likely fostered a scientifically driven, innovative, and patient-focused work culture, emphasizing collaboration and a commitment to addressing unmet medical needs.
The Boston headquarters was strategically vital, enabling Talaris to leverage the rich biotech ecosystem for partnerships, talent acquisition, and investor relations.
Before merging with Tourmaline Bio, Talaris Therapeutics's operational activities, including R&D and manufacturing, were primarily based in the United States. Its 'global' reach was mainly characterized by its clinical trial sites, which were predominantly located within the U.S. as it advanced its therapies through the regulatory pathway.
222 Berkeley Street, 16th Floor
Boston
MA
USA
Address: 950 S. First Street, Louisville, KY 40203
The Louisville location was chosen for its specific operational capabilities suitable for advanced cell therapy manufacturing and its logistical advantages for supporting clinical studies across the U.S.
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As of April 2025, Talaris Therapeutics' leadership includes:
Talaris Therapeutics has been backed by several prominent investors over the years, including:
The 12-month period leading up to mid-2024 was marked by significant transitions for Talaris Therapeutics, culminating in its October 2023 reverse merger with Tourmaline Bio. This phase involved several executive departures and role changes as the company restructured and wound down its standalone operations. Notably, Talaris's CFO, Mary Kay Fenton, assumed the role of interim CEO before the merger, and subsequently became CEO of the new combined entity, Tourmaline Bio.
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Prior to its merger and subsequent operational wind-down, Talaris Therapeutics likely utilized standard corporate email address formats. The most common format for companies of its type is [first_initial][last]@[domain_name], for example, jdoe@talaristx.com. Other potential formats include [first].[last]@[domain_name]. These email addresses are no longer active.
[first_initial][last]@talaristx.com
Format
mkayfenton@talaristx.com
Example
70%
Success rate
GlobeNewswire • October 19, 2023
Talaris Therapeutics and Tourmaline Bio, Inc. confirmed the successful completion of their merger. The combined entity now operates as Tourmaline Bio, Inc., trading under 'TRML', and will focus on advancing Tourmaline’s lead program, TOUR006....more
GlobeNewswire • July 26, 2023
Talaris announced plans for a further workforce reduction to approximately 10 employees by the end of Q3 2023, alongside the continued wind-down of its legacy programs and reaffirmation of the pending merger with Tourmaline Bio....more
GlobeNewswire • June 22, 2023
Talaris Therapeutics revealed it had signed a definitive merger agreement with Tourmaline Bio, Inc. The merged company plans to concentrate on Tourmaline’s pipeline, supported by a concurrent $75 million private placement by Tourmaline investors....more
Fierce Biotech • February 16, 2023
Talaris Therapeutics announced a major restructuring, including a workforce reduction of about one-third, the discontinuation of its Phase 3 FREEDOM-1 study in living donor kidney transplant patients, and a halt to its Phase 2 FREEDOM-2 study, while initiating a process to explore strategic alternatives....more
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