What Does Sema4 Do?

Total employees950
HeadquartersStamford
Founded2017

Sema4 was a patient-centered health intelligence company dedicated to advancing healthcare through data-driven insights. Founded in 2017 as a spin-off from the Mount Sinai Health System, Sema4 leveraged artificial intelligence and machine learning to analyze large-scale clinical and genomic data, aiming to deliver precision medicine solutions for complex diseases, initially focusing on women's health, oncology, and rare diseases. The company provided advanced genomic testing and services to physicians and patients. In January 2023, Sema4 was acquired by GeneDx, and the combined company now operates under the GeneDx name.

Where Is Sema4's Headquarters?

Sema4 officeSema4 officeSema4 officeSema4 office
*Images sourced via web search. Rights belong to original owners

HQ Function

Served as the main corporate office, housing executive leadership, administrative functions, R&D, and data science teams. It was central to strategic planning and operations.

Notable Features:

The Stamford facilities included modern office spaces and potentially integrated laboratory capabilities, designed to foster collaboration and innovation.

Work Culture:

Sema4's work culture was characterized by a strong emphasis on scientific innovation, data-driven decision-making, and a mission to improve patient outcomes. It fostered a collaborative environment for researchers, clinicians, and technologists.

HQ Significance:

The Stamford headquarters was pivotal as the command center for Sema4's efforts in building its health intelligence platform and expanding its genomic testing services across the United States.

Values Reflected in HQ: The headquarters' focus on advanced technology and data analysis reflected Sema4's core values of innovation, scientific rigor, and transforming healthcare through intelligence.

Location:

Sema4's operations and market focus were primarily within the United States. It offered its health intelligence platform, genomic testing, and data analysis services to healthcare systems, physicians, and patients across the U.S. While it may have engaged in international research collaborations, its core infrastructure, laboratories, and commercial activities were U.S.-based.

Street Address:

333 Ludlow Street

City:

Stamford

State/Province:

Connecticut

Country:

USA

Where Else Does Sema4 Operate Around the World?

Branford, Connecticut/USA

Address: 620 West Main Street & 1 Commercial Street, Branford, CT 06405

Served as a primary hub for Sema4's laboratory services, processing patient samples and generating genomic data for analysis.

New York, New York/USA

Address: 142 East 30th Street, New York, NY (and other Mount Sinai affiliated locations)

Facilitated close ties with the academic and clinical research community in NYC, particularly with Mount Sinai, and supported specialized teams.

Buying Intent Signals for Sema4

Highperformr Signals uncover buying intent and give you clear insights to target the right accounts at the right time — helping your sales, marketing, and GTM teams close more deals, faster.

Notable news
Hiring actively
Corporate Finance
Corporate Finance
Corporate Finance
Corporate Finance
Corporate Finance
*Example signal, not calculated in real time

Who's Leading Sema4? Meet the Executive Team

As of April 2025, Sema4' leadership includes:

Katherine Stueland - Chief Executive Officer (from Feb 2022)
Eric Schadt, Ph.D. - Founder and Chief R&D Officer (formerly CEO)
Kevin Feeley - Chief Financial Officer (from Aug 2022)
Gustavo Stolovitzky, Ph.D. - Chief Science Officer
Karen White - Chief People Officer
William K. Oh, M.D. - Chief Medical Science Officer

Who's Investing in Sema4?

Sema4 has been backed by several prominent investors over the years, including:

Blackstone
Deerfield Management Company
General Atlantic
Oak HC/FT
Viking Global Investors
Connecticut Innovations
Section 32
Moore Strategic Ventures

What Leadership Changes Has Sema4 Seen Recently?

Hire2
Exits1

Sema4 experienced key leadership changes in the period leading up to its acquisition by GeneDx, including a new CEO and CFO transitions.

Departures

Isaac Ro, Isaac Ro departed from the role of Chief Financial Officer.

New Appointments:

Katherine Stueland, Katherine Stueland was appointed as the new Chief Executive Officer of Sema4.
Kevin Feeley, Kevin Feeley was appointed as the new Chief Financial Officer.

What Technology (Tech Stack) Is Used bySema4?

Discover the tools Sema4 uses. Highperformr reveals the technologies powering your target accounts — helping your sales, marketing, and GTM teams prioritize smarter and close faster.

Sema4 Email Formats and Examples

Sema4 commonly used a standard corporate email format. Based on available information and common practices, the most likely format involved the employee's first and last name.

firstname.lastname@sema4.com

Format

jane.doe@sema4.com

Example

85%

Success rate

What's the Latest News About Sema4?

GenomeWeb • May 16, 2022

Sema4 to Acquire GeneDx, Opko Health Subsidiary, in $623M All-Stock Deal

Sema4 announced its definitive agreement to acquire GeneDx, a leader in genomic testing for rare disorders, from Opko Health. The deal aimed to create a large and comprehensive health information company....more

Sema4 Press Release • February 1, 2022

Sema4 Appoints Katherine Stueland as CEO; Founder Eric Schadt to Become Chief R&D Officer

Sema4 announced the appointment of Katherine Stueland as its new Chief Executive Officer. Founder Eric Schadt, Ph.D., transitioned to the role of Chief R&D Officer....more

Sema4 Press Release • July 22, 2021

Sema4 Completes Business Combination with CM Life Sciences and Will Begin Trading on Nasdaq

Sema4 announced the completion of its business combination with CM Life Sciences, a special purpose acquisition company (SPAC), and began trading on the Nasdaq stock exchange under the ticker 'SMFR'....more

Fierce Biotech • June 1, 2021

Sema4 grabs $121M to build out AI-driven genomic and clinical data platform

Sema4 raised $121 million in a Series C funding round led by existing investor Section 32, with participation from new and existing investors, to further develop its health intelligence platform....more

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