What Does Orna Therapeutics Do?

Total employees166
HeadquartersCambridge
Founded2019

Orna Therapeutics is a biotechnology company pioneering the development of a new class of fully engineered circular RNA (oRNA™) therapies. Their proprietary platform aims to overcome the limitations of traditional linear mRNA by creating oRNA molecules with potentially greater stability, simplified production, and improved immunogenicity profiles. Orna is focused on advancing these therapies for a wide range of diseases, including cancer, genetic disorders, and infectious diseases, with an initial focus on in situ CAR (isCAR™) therapy for oncology.

Where Is Orna Therapeutics's Headquarters?

HQ Function

The Cambridge headquarters serves as the central hub for Orna's research and development, corporate strategy, business development, and administrative operations.

Notable Features:

Located within a modern life sciences complex, the facility likely includes state-of-the-art laboratory spaces for RNA research, cell biology, and preclinical development, alongside collaborative office environments.

Work Culture:

The work culture is expected to be highly innovative, science-driven, and collaborative, characteristic of biotech companies in the competitive Cambridge ecosystem. There's likely a strong emphasis on cutting-edge research, problem-solving, and a fast-paced environment.

HQ Significance:

The Cambridge location provides Orna Therapeutics with unparalleled access to a rich ecosystem of academic institutions (like MIT and Harvard), skilled talent, venture capital, and potential collaborators, fostering innovation and growth.

Values Reflected in HQ: The headquarters' location and design likely reflect Orna's commitment to scientific excellence, innovation, and being at the forefront of therapeutic development.

Location:

Currently, Orna Therapeutics's primary operations are centered in its Cambridge, MA headquarters. While they may engage in global collaborations for research or clinical trials, they do not appear to have other major physical office locations publicly listed. Their therapeutic ambitions, however, are global, aiming to address diseases affecting patients worldwide.

Street Address:

200 Cambridgepark Drive, Suite 2000

City:

Cambridge

State/Province:

MA

Country:

USA

Where Else Does Orna Therapeutics Operate Around the World?

No additional office locations available.

Buying Intent Signals for Orna Therapeutics

Highperformr Signals uncover buying intent and give you clear insights to target the right accounts at the right time — helping your sales, marketing, and GTM teams close more deals, faster.

Notable news
Hiring actively
Corporate Finance
Corporate Finance
Corporate Finance
Corporate Finance
Corporate Finance
*Example signal, not calculated in real time

Who's Leading Orna Therapeutics? Meet the Executive Team

As of April 2025, Orna Therapeutics' leadership includes:

Thomas Ebeling - Chief Executive Officer
Robert Mabry, Ph.D. - Chief Scientific Officer
Nishla Keiser, Ph.D., J.D. - Chief Business Officer
Paul Schmeltzer, J.D. - General Counsel & Secretary
William J. Rote, Ph.D. - Chief Development Officer
Peter H. B. frecuentes - Chief People Officer
Priya Baskaran, Ph.D. - Senior Vice President, Head of Technical Operations

Who's Investing in Orna Therapeutics?

Orna Therapeutics has been backed by several prominent investors over the years, including:

MPM Capital
BioImpact Capital (an MPM affiliate)
F2 Ventures
Kite, a Gilead Company
Bristol Myers Squibb
Astellas Venture Management
Taiho Ventures
PAGSGroup
Sanofi Ventures
Novartis Institutes for BioMedical Research (NIBR)
SoftBank Vision Fund 2
Omega Funds
Agent Capital
Heat Biologics (now NightHawk Biosciences)

What Leadership Changes Has Orna Therapeutics Seen Recently?

Hire2
Exits0

Orna Therapeutics has seen some key additions to its leadership team over the past year, strengthening its development and operational capabilities. No high-profile executive departures have been prominently reported.

New Appointments:

William J. Rote, Ph.D., William J. Rote appointed as Chief Development Officer to lead preclinical and clinical development strategies.
Priya Baskaran, Ph.D., Priya Baskaran joined as SVP, Head of Technical Operations, to oversee CMC and manufacturing scale-up.

What Technology (Tech Stack) Is Used byOrna Therapeutics?

Discover the tools Orna Therapeutics uses. Highperformr reveals the technologies powering your target accounts — helping your sales, marketing, and GTM teams prioritize smarter and close faster.

Orna Therapeutics Email Formats and Examples

Orna Therapeutics likely uses common corporate email formats. Based on industry standards and company size, the most probable formats involve combinations of first name, last name, and initials.

Common formats include [first_initial][last]@ornatx.com (e.g., jdoe@ornatx.com) or [first].[last]@ornatx.com (e.g., jane.doe@ornatx.com).

Format

tebeling@ornatx.com

Example

80%

Success rate

What's the Latest News About Orna Therapeutics?

Orna Therapeutics WebsiteFebruary 7, 2024

Orna Therapeutics Announces Publication in Nature Biotechnology Demonstrating Potential of its Circular RNA (isCAR™) Platform to Generate and Deliver CAR RNA Therapeutics In Vivo

Orna Therapeutics announced a publication in Nature Biotechnology detailing preclinical data that demonstrate the potential of its circular RNA (oRNA) based in situ CAR (isCAR) platform to generate and deliver CAR RNA therapeutics in vivo for the treatment of cancer....more

Orna Therapeutics WebsiteAugust 16, 2023

Orna Therapeutics Appoints William J. Rote, Ph.D., as Chief Development Officer

Orna Therapeutics announced the appointment of William J. Rote, Ph.D., as Chief Development Officer. Dr. Rote brings extensive experience in drug development to lead Orna's programs into clinical stages....more

PR NewswireFebruary 16, 2023

Orna Therapeutics Announces $221 Million Series B Financing to Advance its Pipeline of Circular RNA Therapeutics

Orna Therapeutics announced the closing of a $221 million Series B financing round. The funding will be used to advance its platform and pipeline of oRNA-based therapeutics, including its lead isCAR program into clinical trials....more

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