What Does Orchard Therapeutics - U.S. Do?

Total employees227
HeadquartersBoston
Founded2015

Orchard Therapeutics is a global gene therapy company dedicated to transforming the lives of patients with severe and life-threatening rare diseases through innovative, Ppotentially curative gene therapies. The company's ex vivo autologous hematopoietic stem cell (HSC) gene therapy approach seeks to correct the underlying genetic cause of disease with a single administration. Orchard Therapeutics was acquired by Kyowa Kirin, with the acquisition completed in January 2024. The US operations play a crucial role in clinical development, regulatory affairs, and commercialization efforts in North America.

Where Is Orchard Therapeutics - U.S.'s Headquarters?

HQ Function

Serves as a major hub for US clinical development, medical affairs, regulatory interactions with the FDA, and commercial strategy for North America. It supports the advancement of Orchard's gene therapy pipeline in the US.

Notable Features:

Located in Boston's Seaport District, a vibrant area known for its concentration of life science companies, research institutions, and access to top talent. The offices are typically modern and designed to foster collaboration.

Work Culture:

Prior to acquisition, Orchard Therapeutics was known for a culture focused on scientific innovation, patient-centricity, and a fast-paced environment driven by the urgency of developing treatments for rare diseases. Collaboration and a strong sense of mission were key characteristics.

HQ Significance:

Boston's ecosystem provides strategic advantages, including proximity to world-class academic and medical centers, a skilled workforce, and a supportive environment for biotech innovation. This location is critical for FDA engagement and US market access.

Values Reflected in HQ: The choice of Boston reflects a commitment to innovation, access to scientific excellence, and a strategic focus on one of the world's leading biotech clusters, aligning with values of pioneering science and patient impact.

Location:

Prior to its acquisition by Kyowa Kirin in early 2024, Orchard Therapeutics operated with a significant global presence, primarily centered in the US (Boston, MA and Menlo Park, CA) and the UK (London). These locations supported a wide range of functions including research and development, clinical trial management across multiple countries, regulatory affairs with global health authorities (FDA, EMA), manufacturing and supply chain logistics, and pre-commercial activities. Their global strategy focused on advancing their pipeline of gene therapies for rare diseases to patients worldwide.

Street Address:

100 Northern Avenue

City:

Boston

State/Province:

MA

Country:

USA

Where Else Does Orchard Therapeutics - U.S. Operate Around the World?

London, United Kingdom

Address: 108 Cannon Street, London, EC4N 6EU, UK

Key hub for European operations, engagement with the European Medicines Agency (EMA), and managing clinical trials and commercial activities across Europe.

Menlo Park, CA, USA

Address: 180 Constitution Drive, Menlo Park, CA 94025, USA

Leveraged the San Francisco Bay Area's rich biotech ecosystem, focusing on the technical and manufacturing aspects critical for developing and scaling up gene therapies.

Buying Intent Signals for Orchard Therapeutics - U.S.

Highperformr Signals uncover buying intent and give you clear insights to target the right accounts at the right time — helping your sales, marketing, and GTM teams close more deals, faster.

Notable news
Hiring actively
Corporate Finance
Corporate Finance
Corporate Finance
Corporate Finance
Corporate Finance
*Example signal, not calculated in real time

Who's Leading Orchard Therapeutics - U.S.? Meet the Executive Team

As of April 2025, Orchard Therapeutics - U.S.' leadership includes:

Bobby Gaspar - Former Chief Executive Officer & Co-Founder
Frank Thomas - Former President and Chief Operating Officer
Nicoletta Loggia - Former Chief Technical Officer
Ran Zheng - Former Chief Technical Officer (succeeded N. Loggia)
Mark Rothera - Former President and Chief Executive Officer (succeeded B. Gaspar)

Who's Investing in Orchard Therapeutics - U.S.?

Orchard Therapeutics - U.S. has been backed by several prominent investors over the years, including:

RA Capital Management
Sofinnova Ventures
Forbion Capital Partners
GlaxoSmithKline (GSK)
Temasek
F-Prime Capital
ArrowMark Partners

What Leadership Changes Has Orchard Therapeutics - U.S. Seen Recently?

Hire0
Exits3

The most significant executive event in the last 12 months was the acquisition of Orchard Therapeutics by Kyowa Kirin, completed in January 2024. This typically leads to transitions in the executive leadership of the acquired company. While specific individual announcements might be staggered, the overall leadership structure is now part of Kyowa Kirin.

Departures

Mark Rothera, Likely transitioned out following the completion of the acquisition by Kyowa Kirin.
Frank Thomas, Likely transitioned out following the completion of the acquisition by Kyowa Kirin.
Ran Zheng, Likely transitioned out following the completion of the acquisition by Kyowa Kirin.

New Appointments:

Orchard Therapeutics Leadership, Orchard Therapeutics' leadership and operational structure are being integrated into Kyowa Kirin. Future leadership announcements will reflect this new combined organization.

What Technology (Tech Stack) Is Used byOrchard Therapeutics - U.S.?

Discover the tools Orchard Therapeutics - U.S. uses. Highperformr reveals the technologies powering your target accounts — helping your sales, marketing, and GTM teams prioritize smarter and close faster.

Orchard Therapeutics - U.S. Email Formats and Examples

Orchard Therapeutics, prior to its acquisition, likely utilized common corporate email formats. The most probable format would be based on employee names and their domain 'orchard-tx.com'. Post-acquisition, email formats might transition to Kyowa Kirin's domain.

first.last@orchard-tx.com

Format

jane.doe@orchard-tx.com

Example

70%

Success rate

What's the Latest News About Orchard Therapeutics - U.S.?

FDA.govMarch 18, 2024

Orchard Therapeutics' Libmeldy (OTL-200) Approved by FDA for Metachromatic Leukodystrophy

The U.S. Food and Drug Administration approved Lenmeldy (atidarsagene autotemcel), formerly OTL-200, for the treatment of children with pre-symptomatic late infantile, pre-symptomatic early juvenile, or early symptomatic early juvenile metachromatic leukodystrophy (MLD). This is a significant milestone for Orchard Therapeutics, now part of Kyowa Kirin....more

Kyowa Kirin Press ReleaseJanuary 24, 2024

Orchard Therapeutics Acquired by Kyowa Kirin in Deal Valued at $477.6M

Kyowa Kirin Co., Ltd. announced the successful completion of the acquisition of Orchard Therapeutics plc. This strategic acquisition is expected to bolster Kyowa Kirin's pipeline with Orchard's innovative gene therapies for rare diseases....more

Orchard Therapeutics Press ReleaseOctober 05, 2023

Orchard Therapeutics to be Acquired by Kyowa Kirin for $16.00 per ADS in Cash, Plus CVRs

Orchard Therapeutics announced it had entered into a definitive agreement to be acquired by Kyowa Kirin. The deal valued Orchard at approximately $387.4 million initially, plus contingent value rights (CVRs)....more

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