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Orchard Therapeutics is a global gene therapy company dedicated to transforming the lives of patients with severe and life-threatening rare diseases through innovative, Ppotentially curative gene therapies. The company's ex vivo autologous hematopoietic stem cell (HSC) gene therapy approach seeks to correct the underlying genetic cause of disease with a single administration. Orchard Therapeutics was acquired by Kyowa Kirin, with the acquisition completed in January 2024. The US operations play a crucial role in clinical development, regulatory affairs, and commercialization efforts in North America.
Serves as a major hub for US clinical development, medical affairs, regulatory interactions with the FDA, and commercial strategy for North America. It supports the advancement of Orchard's gene therapy pipeline in the US.
Located in Boston's Seaport District, a vibrant area known for its concentration of life science companies, research institutions, and access to top talent. The offices are typically modern and designed to foster collaboration.
Prior to acquisition, Orchard Therapeutics was known for a culture focused on scientific innovation, patient-centricity, and a fast-paced environment driven by the urgency of developing treatments for rare diseases. Collaboration and a strong sense of mission were key characteristics.
Boston's ecosystem provides strategic advantages, including proximity to world-class academic and medical centers, a skilled workforce, and a supportive environment for biotech innovation. This location is critical for FDA engagement and US market access.
Prior to its acquisition by Kyowa Kirin in early 2024, Orchard Therapeutics operated with a significant global presence, primarily centered in the US (Boston, MA and Menlo Park, CA) and the UK (London). These locations supported a wide range of functions including research and development, clinical trial management across multiple countries, regulatory affairs with global health authorities (FDA, EMA), manufacturing and supply chain logistics, and pre-commercial activities. Their global strategy focused on advancing their pipeline of gene therapies for rare diseases to patients worldwide.
100 Northern Avenue
Boston
MA
USA
Address: 108 Cannon Street, London, EC4N 6EU, UK
Key hub for European operations, engagement with the European Medicines Agency (EMA), and managing clinical trials and commercial activities across Europe.
Address: 180 Constitution Drive, Menlo Park, CA 94025, USA
Leveraged the San Francisco Bay Area's rich biotech ecosystem, focusing on the technical and manufacturing aspects critical for developing and scaling up gene therapies.
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As of April 2025, Orchard Therapeutics - U.S.' leadership includes:
Orchard Therapeutics - U.S. has been backed by several prominent investors over the years, including:
The most significant executive event in the last 12 months was the acquisition of Orchard Therapeutics by Kyowa Kirin, completed in January 2024. This typically leads to transitions in the executive leadership of the acquired company. While specific individual announcements might be staggered, the overall leadership structure is now part of Kyowa Kirin.
Discover the tools Orchard Therapeutics - U.S. uses. Highperformr reveals the technologies powering your target accounts — helping your sales, marketing, and GTM teams prioritize smarter and close faster.
Orchard Therapeutics, prior to its acquisition, likely utilized common corporate email formats. The most probable format would be based on employee names and their domain 'orchard-tx.com'. Post-acquisition, email formats might transition to Kyowa Kirin's domain.
first.last@orchard-tx.com
Format
jane.doe@orchard-tx.com
Example
70%
Success rate
FDA.gov • March 18, 2024
The U.S. Food and Drug Administration approved Lenmeldy (atidarsagene autotemcel), formerly OTL-200, for the treatment of children with pre-symptomatic late infantile, pre-symptomatic early juvenile, or early symptomatic early juvenile metachromatic leukodystrophy (MLD). This is a significant milestone for Orchard Therapeutics, now part of Kyowa Kirin....more
Kyowa Kirin Press Release • January 24, 2024
Kyowa Kirin Co., Ltd. announced the successful completion of the acquisition of Orchard Therapeutics plc. This strategic acquisition is expected to bolster Kyowa Kirin's pipeline with Orchard's innovative gene therapies for rare diseases....more
Orchard Therapeutics Press Release • October 05, 2023
Orchard Therapeutics announced it had entered into a definitive agreement to be acquired by Kyowa Kirin. The deal valued Orchard at approximately $387.4 million initially, plus contingent value rights (CVRs)....more
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