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Neogene Therapeutics, now part of AstraZeneca, is a clinical-stage biotechnology company pioneering the development of next-generation, fully individualized T-cell receptor (TCR) therapies for a broad spectrum of solid tumors. Their approach aims to harness the immune system to target cancer by engineering T-cells with novel TCRs that recognize tumor-specific neoantigens. The acquisition by AstraZeneca in early 2023 aims to accelerate the development of these potentially transformative cancer treatments by leveraging AstraZeneca's global oncology expertise and resources.
Serves as a key research and development hub, focusing on the discovery and development of T-cell therapies. Post-acquisition by AstraZeneca, it contributes to AstraZeneca's broader oncology R&D efforts, particularly in cell therapy.
Located in an area with a high concentration of biotech companies and research institutions. Facilities are equipped with advanced laboratories for cellular and molecular biology research and cGMP manufacturing capabilities for engineered T-cells.
As part of AstraZeneca, the work culture emphasizes scientific rigor, innovation, and collaboration, aligned with AstraZeneca's global standards. Prior to acquisition, Neogene fostered a dynamic, fast-paced startup environment focused on cutting-edge science and translational research.
This location was crucial for Neogene's European operations, R&D activities, and early manufacturing, playing a vital role in advancing its TCR-T therapy pipeline. It now represents an important cell therapy research and development site within AstraZeneca's network.
Prior to its acquisition by AstraZeneca, Neogene Therapeutics operated primarily with headquarters and R&D/manufacturing facilities in Amsterdam, Netherlands, and Santa Monica, California, USA. As part of AstraZeneca, Neogene's innovative TCR-T technologies and programs are now integrated into AstraZeneca's extensive global oncology R&D and clinical operations network. This network spans across North America, Europe, Asia, and other key regions, enabling global clinical trial execution, potential for scaled-up manufacturing, and broader research collaborations worldwide.
Paasheuvelweg 25
Amsterdam
North Holland
Netherlands
Address: 2400 Broadway, Suite 230, Santa Monica, CA 90404, USA
Focused on US-based clinical trial management, engagement with regulatory authorities like the FDA, and leveraging the strong biotech ecosystem in California for talent and collaborations. Key for advancing Neogene's therapies through US clinical pathways.
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As of April 2025, Neogene Therapeutics' leadership includes:
Neogene Therapeutics has been backed by several prominent investors over the years, including:
Following the acquisition by AstraZeneca, completed in January 2023, key leadership from Neogene Therapeutics transitioned into significant roles within AstraZeneca's newly formed cell therapy unit. This integration aims to leverage Neogene's expertise to accelerate AstraZeneca's ambitions in oncology cell therapy.
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Following its acquisition by AstraZeneca, employees previously with Neogene Therapeutics are integrated into AstraZeneca's communication systems. The standard email format for AstraZeneca is typically firstname.lastname@astrazeneca.com. Emails to former Neogene-specific addresses (e.g., @neogene.com) may no longer be active or are likely forwarded to AstraZeneca accounts.
firstname.lastname@astrazeneca.com
Format
john.smith@astrazeneca.com
Example
95%
Success rate
AstraZeneca • January 24, 2023
AstraZeneca has completed the acquisition of Neogene Therapeutics Inc., a clinical-stage biotechnology company pioneering the development of next-generation T-cell receptor therapies (TCR-Ts) for solid tumours. The acquisition strengthens AstraZeneca’s capabilities in cell therapy and includes an upfront payment of $200m, with up to $120m in additional contingent milestones....more
Neogene Therapeutics (via BusinessWire) • November 29, 2022
AstraZeneca announced it has entered into a definitive agreement to acquire Neogene Therapeutics Inc. for a total consideration of up to $320m. Neogene is focused on discovering, developing and manufacturing next-generation TCR therapies targeting neoantigens for the treatment of solid tumors. The acquisition is expected to close in the first quarter of 2023....more
Neogene Therapeutics (via PR Newswire) • December 6, 2021
Neogene Therapeutics, a pre-clinical stage biotechnology company, announced the closing of a $110 million (€97 million) Series A financing round. The financing was co-led by EcoR1 Capital, Jeito Capital, and Syncona, with continued support from founding investors Vida Ventures, TPG, and Two River. Funds were to be used to advance Neogene's pipeline of TCR therapies....more
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