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Maverick Therapeutics, Inc. was a private, clinical-stage biotechnology company dedicated to revolutionizing cancer treatment by developing novel T-cell engaging immunotherapies. Their proprietary COBRA™ (Conditional Bispecific Redirected Activation) platform was designed to create potent yet safer T-cell engagers that are inactive until they reach the tumor microenvironment. This approach aimed to overcome the toxicity limitations of conventional T-cell engagers. Founded in 2016 as a spin-out from Takeda and MPM Capital, Maverick made significant advancements in its conditionally active bispecific antibodies. In March 2021, Takeda Pharmaceutical Company Limited acquired Maverick Therapeutics, integrating its promising COBRA platform and pipeline into Takeda's oncology portfolio to accelerate the development of next-generation cancer treatments.
Primary hub for research and development of its COBRA™ platform and T-cell engager immunotherapies, including preclinical research, process development, and clinical trial management.
Located in a modern biotech park, the facility likely housed state-of-the-art laboratories for antibody engineering, cell biology, and bioanalytical work, alongside office spaces.
As a venture-backed biotech, Maverick fostered an innovative, fast-paced, and science-driven work culture. Emphasis was placed on collaboration, scientific excellence, and a shared mission to develop transformative cancer therapies.
The Brisbane headquarters was the nerve center for Maverick's pioneering work on conditionally active T-cell engagers, leading to the development of its lead candidates and ultimately attracting acquisition by Takeda.
Prior to its acquisition by Takeda, Maverick Therapeutics' operations were primarily concentrated in the United States, with its headquarters and R&D activities based in Brisbane, California. It did not have a significant independent global operational footprint. Post-acquisition, its innovative COBRA™ platform and pipeline assets contribute to Takeda's global oncology research and development programs, which span multiple countries.
2000 Sierra Point Parkway, Suite 400
Brisbane
CA
USA
No additional office locations available.
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As of April 2025, Maverick Therapeutics' leadership includes:
Maverick Therapeutics has been backed by several prominent investors over the years, including:
Maverick Therapeutics was acquired by Takeda in March 2021 and ceased to operate as an independent entity. Therefore, there have been no executive hires or exits specifically for 'Maverick Therapeutics' as a standalone company in the last 12 months. Leadership and personnel were integrated into Takeda or transitioned at the time of acquisition.
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Prior to its acquisition by Takeda, Maverick Therapeutics likely used common corporate email formats. As the company is now part of Takeda and mavericktx.com is likely inactive, these formats are historical.
[first_initial][last]@mavericktx.com
Format
jdoe@mavericktx.com
Example
0 (domain likely inactive post-acquisition)%
Success rate
Takeda Pharmaceuticals • March 9, 2021
Takeda Pharmaceutical Company Limited announced it exercised its option to acquire Maverick Therapeutics, Inc., for a pre-negotiated upfront payment as well as potential development and regulatory milestones totaling up to $525 million. The acquisition brought Maverick’s T-cell engager COBRA platform and development candidates, including MVC-101 (now TAK-186) and MVC-280 (now TAK-280), into Takeda's oncology portfolio....more
PR Newswire • January 7, 2019
Maverick Therapeutics announced the advancement of its lead development candidate, MVC-101, a conditionally active T-cell engager targeting EGFR on tumor cells, into formal GLP toxicology studies. This marked a key step towards clinical development....more
FierceBiotech • September 5, 2017
Maverick Therapeutics was officially launched, spun out of Takeda with a $120 million Series B financing co-led by Takeda and MPM Capital. The company was formed to advance a portfolio of T-cell engagement therapies based on a novel platform....more
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