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Histogenics Corporation was a regenerative medicine company focused on developing and commercializing products in the musculoskeletal segment, primarily its NeoCart® autologous cell therapy for knee cartilage repair. Founded in 2000, the company progressed NeoCart® through Phase 3 clinical trials. However, after disappointing trial results in late 2018, Histogenics underwent significant restructuring, filed for Chapter 11 bankruptcy in May 2019, and subsequently merged with Ocugen, Inc. in September 2019. The combined entity operates as Ocugen.
The Waltham headquarters served as the main hub for Histogenics' corporate administration, research and development activities, and clinical trial operations management.
The facility was likely standard for a biotech company of its size, comprising office spaces and potentially some laboratory facilities, situated within a modern office park.
As a clinical-stage biopharmaceutical company, the work culture at Histogenics likely emphasized scientific innovation, rigorous research, and a strong focus on achieving clinical milestones. It would have been a dynamic environment, particularly during its active clinical trial phases.
This headquarters was the nerve center for the development of NeoCart® and represented the company's strategic presence in a key U.S. biotech cluster, facilitating access to talent and resources.
Histogenics' core operations, including research, clinical development, and manufacturing, were primarily concentrated in the United States. While its main focus was the U.S. market, Histogenics did engage in some international activities, such as a partnership with MEDINET Co., Ltd. for the potential development and commercialization of NeoCart® in Japan. However, its direct operational footprint remained largely U.S.-based prior to its merger.
830 Winter Street, Suite 300
Waltham
MA
USA
Address: 200 Forest Street, Marlborough, MA 01752 (approx.)
The Marlborough facility was crucial for producing NeoCart® supplies for clinical trials and was being prepared for potential commercial-scale manufacturing, leveraging Massachusetts' biotech manufacturing infrastructure.
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As of April 2025, Histogenics Corporation' leadership includes:
Histogenics Corporation has been backed by several prominent investors over the years, including:
In the 12-18 months preceding its merger with Ocugen in late 2019, Histogenics experienced significant executive team changes. These were largely driven by restructuring efforts following clinical trial setbacks for NeoCart and the company's subsequent Chapter 11 bankruptcy filing.
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For companies like Histogenics, a common email format was typically the first initial followed by the last name, or first name separated by a dot from the last name, at the company domain.
[first_initial][last]@histogenics.com
Format
agridley@histogenics.com
Example
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Success rate
GlobeNewswire • September 6, 2018
Histogenics reported that its Phase 3 clinical trial of NeoCart for knee cartilage repair did not meet its primary endpoint of demonstrating a statistically significant improvement in pain and function compared to microfracture treatment at one year post-treatment....more
SEC Filing (8-K) • May 20, 2019
Histogenics Corporation announced that it and its wholly-owned subsidiary, Histogenics SSC, Inc., filed voluntary petitions for reorganization under Chapter 11 of the U.S. Bankruptcy Code. This was intended to facilitate its previously announced merger agreement with Ocugen, Inc....more
GlobeNewswire • September 27, 2019
Ocugen, Inc. and Histogenics Corporation announced the completion of their merger. The combined, publicly traded company now operates under the name Ocugen, Inc. (NASDAQ: OCGN) and focuses on Ocugen's pipeline of ophthalmology and novel gene therapy candidates. Histogenics common stock ceased trading....more
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