What Does Harpoon Therapeutics Do?

Total employees26
HeadquartersSouth San Francisco
Founded2015

Harpoon Therapeutics was a clinical-stage immunotherapy company dedicated to developing novel T cell engagers for the treatment of cancer. Its proprietary platform, Tri-specific T cell Activating Constructs (TriTAC®), was designed to harness a patient's own immune system to attack tumor cells. The company's pipeline included candidates targeting various hematological malignancies and solid tumors, such as HPN328 for small cell lung cancer. In January 2024, Merck (known as MSD outside the U.S. and Canada) announced its intent to acquire Harpoon Therapeutics for approximately $680 million. The acquisition was completed in April 2024, integrating Harpoon's innovative T cell engager technology and pipeline into Merck's oncology portfolio.

Where Is Harpoon Therapeutics's Headquarters?

HQ Function

Prior to its acquisition by Merck, the headquarters served as the central hub for Harpoon's research and development, clinical operations, and corporate administration.

Notable Features:

Located within a modern biotechnology park, the facility likely featured advanced laboratory spaces, R&D equipment, and collaborative office environments suitable for a clinical-stage biopharmaceutical company.

Work Culture:

As a clinical-stage biotech, the work culture was likely dynamic, science-driven, and highly focused on innovation and achieving clinical milestones. Collaboration, agility, and a commitment to addressing unmet medical needs in oncology would have been key characteristics. Post-acquisition, employees and operations are integrated into Merck's corporate culture.

HQ Significance:

The South San Francisco location provided strategic advantages, including proximity to a rich talent pool, leading academic institutions, potential collaborators, and a vibrant biotech ecosystem.

Values Reflected in HQ: The headquarters would have reflected values such as scientific excellence, innovation, patient focus, and teamwork, essential for advancing novel cancer therapies.

Location:

Before being acquired by Merck, Harpoon Therapeutics' global functions were primarily focused on the execution of its clinical development programs. This involved managing clinical trial sites and collaborating with investigators and CROs in North America and potentially other international regions to advance its pipeline of T cell engagers. The company did not operate a widespread network of international offices; its strategic and operational oversight was centralized at its U.S. headquarters. Its assets and programs are now part of Merck's extensive global oncology operations.

Street Address:

131 Oyster Point Blvd, Suite 300

City:

South San Francisco

State/Province:

CA

Country:

USA

Where Else Does Harpoon Therapeutics Operate Around the World?

N/A - Operations Centralized

Address: Not Applicable - Clinical trial operations managed via CROs

To support global clinical trial execution, patient enrollment, and regulatory interactions in key geographical areas by leveraging the infrastructure and expertise of specialized CROs, rather than establishing standalone regional offices.

Buying Intent Signals for Harpoon Therapeutics

Highperformr Signals uncover buying intent and give you clear insights to target the right accounts at the right time — helping your sales, marketing, and GTM teams close more deals, faster.

Notable news
Hiring actively
Corporate Finance
Corporate Finance
Corporate Finance
Corporate Finance
Corporate Finance
*Example signal, not calculated in real time

Who's Leading Harpoon Therapeutics? Meet the Executive Team

As of April 2025, Harpoon Therapeutics' leadership includes:

Julie M. Eastland - Former President and Chief Executive Officer
Luke Walker - Former Chief Financial Officer
Holger Kanzler, Ph.D. - Former Chief Scientific Officer
Lauren Musto - Former Chief People Officer

Who's Investing in Harpoon Therapeutics?

Harpoon Therapeutics has been backed by several prominent investors over the years, including:

MPM Capital
New Leaf Venture Partners
Arix Bioscience PLC
OrbiMed
SR One
Taiho Ventures
alphabet_soup_llc

What Leadership Changes Has Harpoon Therapeutics Seen Recently?

Hire0
Exits4

The most significant executive changes at Harpoon Therapeutics were a direct result of its acquisition by Merck, completed in April 2024. This event led to the transition of its existing leadership team as the company's operations and personnel were integrated into Merck.

Departures

Julie M. Eastland, Role concluded following the completion of Merck's acquisition of Harpoon Therapeutics.
Luke Walker, Role concluded following the completion of Merck's acquisition of Harpoon Therapeutics.
Holger Kanzler, Ph.D., Role concluded following the completion of Merck's acquisition of Harpoon Therapeutics.
Lauren Musto, Role concluded following the completion of Merck's acquisition of Harpoon Therapeutics.

What Technology (Tech Stack) Is Used byHarpoon Therapeutics?

Discover the tools Harpoon Therapeutics uses. Highperformr reveals the technologies powering your target accounts — helping your sales, marketing, and GTM teams prioritize smarter and close faster.

Harpoon Therapeutics Email Formats and Examples

Prior to its acquisition by Merck, Harpoon Therapeutics likely utilized a common corporate email format, such as first initial followed by last name, or first name.last name, at their domain harpoontx.com. This domain is no longer actively used for independent company communications.

flast@harpoontx.com

Format

jdoe@harpoontx.com

Example

0%

Success rate

What's the Latest News About Harpoon Therapeutics?

Merck NewsApril 10, 2024

Merck Completes Acquisition of Harpoon Therapeutics, Inc.

Merck announced the successful completion of its acquisition of Harpoon Therapeutics, Inc. Following the acquisition, Harpoon became a wholly owned subsidiary of Merck, and its common stock ceased to be publicly traded....more

Merck NewsJanuary 8, 2024

Merck to Acquire Harpoon Therapeutics, Inc.

Merck and Harpoon Therapeutics announced a definitive agreement under which Merck would acquire Harpoon for $23.00 per share in cash, for an approximate total equity value of $680 million. The acquisition aimed to bolster Merck's oncology pipeline with Harpoon's novel T-cell engagers....more

GlobeNewswireOctober 26, 2023

Harpoon Therapeutics Announces Encouraging Initial Dose Escalation Data for HPN328 in Patients with Small Cell Lung Cancer and Other Neuroendocrine Tumor Types

Harpoon Therapeutics presented positive interim data from its Phase 1/2 clinical trial of HPN328, a DLL3-targeting TriTAC®. The data showed a manageable safety profile and early signs of anti-tumor activity in heavily pretreated patients....more

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