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Harpoon Therapeutics was a clinical-stage immunotherapy company dedicated to developing novel T cell engagers for the treatment of cancer. Its proprietary platform, Tri-specific T cell Activating Constructs (TriTAC®), was designed to harness a patient's own immune system to attack tumor cells. The company's pipeline included candidates targeting various hematological malignancies and solid tumors, such as HPN328 for small cell lung cancer. In January 2024, Merck (known as MSD outside the U.S. and Canada) announced its intent to acquire Harpoon Therapeutics for approximately $680 million. The acquisition was completed in April 2024, integrating Harpoon's innovative T cell engager technology and pipeline into Merck's oncology portfolio.
Prior to its acquisition by Merck, the headquarters served as the central hub for Harpoon's research and development, clinical operations, and corporate administration.
Located within a modern biotechnology park, the facility likely featured advanced laboratory spaces, R&D equipment, and collaborative office environments suitable for a clinical-stage biopharmaceutical company.
As a clinical-stage biotech, the work culture was likely dynamic, science-driven, and highly focused on innovation and achieving clinical milestones. Collaboration, agility, and a commitment to addressing unmet medical needs in oncology would have been key characteristics. Post-acquisition, employees and operations are integrated into Merck's corporate culture.
The South San Francisco location provided strategic advantages, including proximity to a rich talent pool, leading academic institutions, potential collaborators, and a vibrant biotech ecosystem.
Before being acquired by Merck, Harpoon Therapeutics' global functions were primarily focused on the execution of its clinical development programs. This involved managing clinical trial sites and collaborating with investigators and CROs in North America and potentially other international regions to advance its pipeline of T cell engagers. The company did not operate a widespread network of international offices; its strategic and operational oversight was centralized at its U.S. headquarters. Its assets and programs are now part of Merck's extensive global oncology operations.
131 Oyster Point Blvd, Suite 300
South San Francisco
CA
USA
Address: Not Applicable - Clinical trial operations managed via CROs
To support global clinical trial execution, patient enrollment, and regulatory interactions in key geographical areas by leveraging the infrastructure and expertise of specialized CROs, rather than establishing standalone regional offices.
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As of April 2025, Harpoon Therapeutics' leadership includes:
Harpoon Therapeutics has been backed by several prominent investors over the years, including:
The most significant executive changes at Harpoon Therapeutics were a direct result of its acquisition by Merck, completed in April 2024. This event led to the transition of its existing leadership team as the company's operations and personnel were integrated into Merck.
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Prior to its acquisition by Merck, Harpoon Therapeutics likely utilized a common corporate email format, such as first initial followed by last name, or first name.last name, at their domain harpoontx.com. This domain is no longer actively used for independent company communications.
flast@harpoontx.com
Format
jdoe@harpoontx.com
Example
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Success rate
Merck News • April 10, 2024
Merck announced the successful completion of its acquisition of Harpoon Therapeutics, Inc. Following the acquisition, Harpoon became a wholly owned subsidiary of Merck, and its common stock ceased to be publicly traded....more
Merck News • January 8, 2024
Merck and Harpoon Therapeutics announced a definitive agreement under which Merck would acquire Harpoon for $23.00 per share in cash, for an approximate total equity value of $680 million. The acquisition aimed to bolster Merck's oncology pipeline with Harpoon's novel T-cell engagers....more
GlobeNewswire • October 26, 2023
Harpoon Therapeutics presented positive interim data from its Phase 1/2 clinical trial of HPN328, a DLL3-targeting TriTAC®. The data showed a manageable safety profile and early signs of anti-tumor activity in heavily pretreated patients....more
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