What Does Fulcrum Therapeutics Do?

Total employees66
HeadquartersCambridge
Founded2016

Fulcrum Therapeutics is a clinical-stage biopharmaceutical company focused on improving the lives of patients with genetically defined rare diseases by pioneering a small molecule, targeted approach to R&D. The company's proprietary product engine, FulcrumSeek™, identifies drug targets that can modulate gene expression to address the root cause of genetically defined rare diseases. Fulcrum's lead clinical programs are losmapimod for facioscapulohumeral muscular dystrophy (FSHD) and FTX-6058 for sickle cell disease. Their approach aims to deliver a new generation of therapies that fundamentally alter the course of these debilitating conditions.

Where Is Fulcrum Therapeutics's Headquarters?

HQ Function

The Cambridge headquarters serves as the company's primary center for research and development, clinical operations, corporate strategy, and administrative functions.

Notable Features:

Located in the heart of Kendall Square, the facility benefits from proximity to world-class academic institutions, research organizations, and a dense cluster of biotech and pharmaceutical companies, fostering a collaborative and innovative environment. The space likely includes state-of-the-art laboratories and modern office layouts.

Work Culture:

Fulcrum Therapeutics cultivates a science-driven, patient-centric, and collaborative work culture. Employees are typically highly motivated by the mission to address unmet needs in rare diseases, with an emphasis on teamwork, scientific rigor, and innovation.

HQ Significance:

The headquarters' location in Cambridge is critical for attracting top scientific talent, facilitating collaborations with leading researchers and institutions, and staying at the forefront of biotechnological advancements.

Values Reflected in HQ: The headquarters' design and location reflect Fulcrum's core values of scientific excellence, innovation, urgency in addressing patient needs, and collaboration, providing an environment conducive to cutting-edge research and development.

Location:

While Fulcrum Therapeutics is headquartered in the United States, its operations, particularly clinical trials for its rare disease therapies, often involve international sites to ensure diverse patient recruitment and global reach. The company's research aims to address diseases affecting patients worldwide, and its business development and potential commercialization strategies may include global partnerships and markets.

Street Address:

26 Landsdowne Street

City:

Cambridge

State/Province:

MA

Country:

USA

Where Else Does Fulcrum Therapeutics Operate Around the World?

No additional office locations available.

Buying Intent Signals for Fulcrum Therapeutics

Highperformr Signals uncover buying intent and give you clear insights to target the right accounts at the right time — helping your sales, marketing, and GTM teams close more deals, faster.

Notable news
Hiring actively
Corporate Finance
Corporate Finance
Corporate Finance
Corporate Finance
Corporate Finance
*Example signal, not calculated in real time

Who's Leading Fulcrum Therapeutics? Meet the Executive Team

As of April 2025, Fulcrum Therapeutics' leadership includes:

Alex C. Sapir - President and Chief Executive Officer
EstherRAJ translateX. Lee - Chief Financial Officer
Santiago Arroyo, M.D., Ph.D. - Chief Medical Officer
Iain Fraser, D.Phil. - Chief Scientific Officer
Sonya G. D'Andrea, J.D., Ph.D. - Chief Legal Officer and Corporate Secretary
Melody Brown - Chief People Officer

Who's Investing in Fulcrum Therapeutics?

Fulcrum Therapeutics has been backed by several prominent investors over the years, including:

Third Rock Ventures
Foresite Capital
RA Capital Management
GV (Google Ventures)
FMR LLC (Fidelity Management & Research Company)
Casdin Capital
Perceptive Advisors

What Leadership Changes Has Fulcrum Therapeutics Seen Recently?

Hire5
Exits2

Fulcrum Therapeutics has undergone significant leadership renewal over the past 12 months (approx. May 2023 - May 2024), with key appointments including a new CEO, CFO, CMO, CPO, and CLO, aimed at guiding the company's clinical programs and strategic objectives. There was also a CEO transition and a departure of the President of R&D.

Departures

Bryan Stuart, Bryan Stuart stepped down as President and CEO.
Judith Dunn, Ph.D., Judith Dunn, former President, R&D, departed from the company as part of a strategic update.

New Appointments:

Alex C. Sapir, Alex C. Sapir formally appointed President and CEO, after serving as Interim President and CEO since July 2023.
EstherRAJ translateX. Lee, EstherRAJ translateX. Lee joined Fulcrum Therapeutics as Chief Financial Officer.
Santiago Arroyo, M.D., Ph.D., Santiago Arroyo appointed as Chief Medical Officer to lead clinical development.
Sonya G. D'Andrea, J.D., Ph.D., Sonya G. D'Andrea appointed as Chief Legal Officer and Corporate Secretary.
Melody Brown, Melody Brown joined as Chief People Officer to lead human resources and talent strategy.

What Technology (Tech Stack) Is Used byFulcrum Therapeutics?

Discover the tools Fulcrum Therapeutics uses. Highperformr reveals the technologies powering your target accounts — helping your sales, marketing, and GTM teams prioritize smarter and close faster.

Fulcrum Therapeutics Email Formats and Examples

Fulcrum Therapeutics commonly uses the email format of the first initial followed by the last name. For example, if an employee's name is Jane Doe, her email address would likely be jdoe@fulcrumtx.com. This is a standard convention for many companies in the biopharmaceutical industry.

[first_initial][last]@fulcrumtx.com

Format

jdoe@fulcrumtx.com

Example

80%

Success rate

What's the Latest News About Fulcrum Therapeutics?

Business WireMay 15, 2024

Fulcrum Therapeutics Announces Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)

Fulcrum Therapeutics announced that the Compensation Committee of Fulcrum's Board of Directors approved inducement stock options to purchase an aggregate of 260,000 shares of common stock to three new employees, granted as an inducement material to the new employees entering into employment with Fulcrum....more

Business WireMay 9, 2024

Fulcrum Therapeutics Reports First Quarter 2024 Financial Results and Provides Business Update

Fulcrum Therapeutics reported its financial results for Q1 2024, highlighting progress in its clinical programs for FSHD and sickle cell disease, including enrollment updates for REACH Phase 1b trial of FTX-6058 and plans for losmapimod....more

Business WireMay 7, 2024

Fulcrum Therapeutics to Present at the Citizens JMP Life Sciences Conference

Fulcrum Therapeutics announced that its President and CEO, Alex C. Sapir, would present at the Citizens JMP Life Sciences Conference on May 13, 2024, providing an overview of the company's progress and outlook....more

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