What Does Entasis Therapeutics Do?

Total employees9
HeadquartersWaltham
Founded2015

Entasis Therapeutics, acquired by Innoviva in 2022, was a clinical-stage biopharmaceutical company focused on the discovery, development, and commercialization of novel antibacterial products to treat serious infections caused by multidrug-resistant Gram-negative bacteria. Their pathogen-targeted approach aimed to address critical unmet medical needs by developing differentiated, small-molecule PBP inhibitors, β-lactamase inhibitors, and other innovative therapies. Key programs included SUL-DUR (sulbactam-durlobactam), which received FDA approval as XACDURO®, and zoliflodacin.

Where Is Entasis Therapeutics's Headquarters?

HQ Function

Served as the primary center for research and development, corporate operations, and strategic planning for its antibacterial drug pipeline before being integrated into Innoviva.

Notable Features:

The facility housed advanced laboratory spaces designed for microbiological research, medicinal chemistry, and biopharmaceutical development.

Work Culture:

Prior to acquisition, Entasis fostered a science-driven, innovative, and collaborative environment. Employees were deeply committed to the mission of combating antimicrobial resistance and developing novel therapies for patients with critical infections.

HQ Significance:

The Waltham headquarters was the core of Entasis's R&D engine, driving the progression of its novel antibiotic candidates from discovery through clinical trials.

Values Reflected in HQ: The headquarters reflected values of scientific rigor, innovation in drug discovery, patient-centricity, and a sense of urgency in addressing the global threat of antibiotic-resistant infections.

Location:

Before its acquisition by Innoviva, Entasis Therapeutics's global presence was mainly characterized by its efforts to address worldwide health challenges posed by antimicrobial resistance. This involved conducting international clinical trials for its drug candidates, such as SUL-DUR and zoliflodacin, across various countries to ensure diverse patient data and meet global regulatory standards for potential commercialization. Research collaborations and partnerships also extended its scientific reach internationally.

Street Address:

35 Gatehouse Drive

City:

Waltham

State/Province:

MA

Country:

USA

Where Else Does Entasis Therapeutics Operate Around the World?

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Address: N/A

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Buying Intent Signals for Entasis Therapeutics

Highperformr Signals uncover buying intent and give you clear insights to target the right accounts at the right time — helping your sales, marketing, and GTM teams close more deals, faster.

Notable news
Hiring actively
Corporate Finance
Corporate Finance
Corporate Finance
Corporate Finance
Corporate Finance
*Example signal, not calculated in real time

Who's Leading Entasis Therapeutics? Meet the Executive Team

As of April 2025, Entasis Therapeutics' leadership includes:

Manos Perros, Ph.D. - Former Chief Executive Officer
Michael Gutch, Ph.D. - Former Chief Financial Officer and Chief Business Officer
Robin Isaacs, M.D. - Former Chief Medical Officer
John Mueller, Ph.D. - Former Chief Development Officer
Anna Diaz-Triola, J.D. - Former Chief Administrative Officer & General Counsel

Who's Investing in Entasis Therapeutics?

Entasis Therapeutics has been backed by several prominent investors over the years, including:

AstraZeneca (Initial Funder/Spin-out)
Clarus Ventures
Frazier Healthcare Partners
Pivotal bioVenture Partners
Innoviva (Acquirer)

What Leadership Changes Has Entasis Therapeutics Seen Recently?

Hire0
Exits0

Entasis Therapeutics was fully acquired by Innoviva, with the transaction completed in July 2022. As a result, the executive team of Entasis was integrated into Innoviva or transitioned out at that time. In the last 12 months, Entasis has operated as part of Innoviva, and any significant leadership changes related to its former pipeline would be announced under Innoviva's corporate structure. There have been no publicly announced Entasis-specific executive hires or exits as a standalone entity in the past year.

What Technology (Tech Stack) Is Used byEntasis Therapeutics?

Discover the tools Entasis Therapeutics uses. Highperformr reveals the technologies powering your target accounts — helping your sales, marketing, and GTM teams prioritize smarter and close faster.

Entasis Therapeutics Email Formats and Examples

Prior to its acquisition by Innoviva and the discontinuation of its standalone operations, Entasis Therapeutics likely used common corporate email address formats. The domain 'entasistx.com' is no longer active for email for Entasis as an independent company.

Common formats for similar companies include [first_initial][last]@entasistx.com (e.g., jdoe@entasistx.com) or [first].[last]@entasistx.com (e.g., jane.doe@entasistx.com).

Format

jsmith@entasistx.com (example, historical)

Example

70%

Success rate

What's the Latest News About Entasis Therapeutics?

Business Wire / InnovivaMay 24, 2023

Innoviva Announces FDA Approval of XACDURO® (sulbactam-durlobactam), Developed by Entasis Therapeutics, for Acinetobacter Infections

Innoviva announced that the U.S. Food and Drug Administration (FDA) approved XACDURO® (sulbactam for injection; durlobactam for injection) for the treatment of patients 18 years of age and older with hospital-acquired bacterial pneumonia (HABP) and ventilator-associated bacterial pneumonia (VABP) caused by susceptible strains of Acinetobacter baumannii-calcoaceticus complex (Acinetobacter). XACDURO was developed by Entasis Therapeutics, which was acquired by Innoviva....more

GARDP (Global Antibiotic Research and Development Partnership)November 9, 2022

GARDP and Entasis (now Innoviva) Complete Patient Enrolment for Pivotal Phase 3 Trial of Zoliflodacin for Gonorrhea

The Global Antibiotic Research and Development Partnership (GARDP) and Entasis Therapeutics announced the completion of patient enrolment in the pivotal Phase 3 clinical trial investigating zoliflodacin, a novel, first-in-class oral antibiotic, for the treatment of uncomplicated gonorrhea. Entasis Therapeutics, now part of Innoviva, originally developed zoliflodacin....more

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