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Entasis Therapeutics, acquired by Innoviva in 2022, was a clinical-stage biopharmaceutical company focused on the discovery, development, and commercialization of novel antibacterial products to treat serious infections caused by multidrug-resistant Gram-negative bacteria. Their pathogen-targeted approach aimed to address critical unmet medical needs by developing differentiated, small-molecule PBP inhibitors, β-lactamase inhibitors, and other innovative therapies. Key programs included SUL-DUR (sulbactam-durlobactam), which received FDA approval as XACDURO®, and zoliflodacin.
Served as the primary center for research and development, corporate operations, and strategic planning for its antibacterial drug pipeline before being integrated into Innoviva.
The facility housed advanced laboratory spaces designed for microbiological research, medicinal chemistry, and biopharmaceutical development.
Prior to acquisition, Entasis fostered a science-driven, innovative, and collaborative environment. Employees were deeply committed to the mission of combating antimicrobial resistance and developing novel therapies for patients with critical infections.
The Waltham headquarters was the core of Entasis's R&D engine, driving the progression of its novel antibiotic candidates from discovery through clinical trials.
Before its acquisition by Innoviva, Entasis Therapeutics's global presence was mainly characterized by its efforts to address worldwide health challenges posed by antimicrobial resistance. This involved conducting international clinical trials for its drug candidates, such as SUL-DUR and zoliflodacin, across various countries to ensure diverse patient data and meet global regulatory standards for potential commercialization. Research collaborations and partnerships also extended its scientific reach internationally.
35 Gatehouse Drive
Waltham
MA
USA
Address: N/A
N/A
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As of April 2025, Entasis Therapeutics' leadership includes:
Entasis Therapeutics has been backed by several prominent investors over the years, including:
Entasis Therapeutics was fully acquired by Innoviva, with the transaction completed in July 2022. As a result, the executive team of Entasis was integrated into Innoviva or transitioned out at that time. In the last 12 months, Entasis has operated as part of Innoviva, and any significant leadership changes related to its former pipeline would be announced under Innoviva's corporate structure. There have been no publicly announced Entasis-specific executive hires or exits as a standalone entity in the past year.
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Prior to its acquisition by Innoviva and the discontinuation of its standalone operations, Entasis Therapeutics likely used common corporate email address formats. The domain 'entasistx.com' is no longer active for email for Entasis as an independent company.
Common formats for similar companies include [first_initial][last]@entasistx.com (e.g., jdoe@entasistx.com) or [first].[last]@entasistx.com (e.g., jane.doe@entasistx.com).
Format
jsmith@entasistx.com (example, historical)
Example
70%
Success rate
Business Wire / Innoviva • May 24, 2023
Innoviva announced that the U.S. Food and Drug Administration (FDA) approved XACDURO® (sulbactam for injection; durlobactam for injection) for the treatment of patients 18 years of age and older with hospital-acquired bacterial pneumonia (HABP) and ventilator-associated bacterial pneumonia (VABP) caused by susceptible strains of Acinetobacter baumannii-calcoaceticus complex (Acinetobacter). XACDURO was developed by Entasis Therapeutics, which was acquired by Innoviva....more
GARDP (Global Antibiotic Research and Development Partnership) • November 9, 2022
The Global Antibiotic Research and Development Partnership (GARDP) and Entasis Therapeutics announced the completion of patient enrolment in the pivotal Phase 3 clinical trial investigating zoliflodacin, a novel, first-in-class oral antibiotic, for the treatment of uncomplicated gonorrhea. Entasis Therapeutics, now part of Innoviva, originally developed zoliflodacin....more
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