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Engine Biosciences's Overview

Total employees32
HeadquartersSingapore
Founded

Engine Biosciences is a venture-backed biotechnology company at the forefront of network biomedicine. They integrate proprietary machine learning algorithms (NetMAPPR®) and high-throughput wet lab validation (CombiGEM™) to decipher complex disease biology and accelerate the discovery of novel precision medicine therapies. Their primary focus is on oncology, particularly targeting genetically defined patient populations with high unmet medical needs. By identifying and validating novel drug targets and biomarkers, Engine Biosciences aims to develop impactful treatments that improve patient outcomes.

Where is Engine Biosciences's Headquarters?

HQ Function

Serves as the central hub for research and development, corporate strategy, and operational management. Key activities include computational biology, wet-lab experimentation, and drug discovery program leadership.

Notable Features:

Located within Biopolis, Singapore's world-class biomedical sciences research park, providing access to state-of-the-art facilities, a rich scientific ecosystem, and opportunities for collaboration.

Work Culture:

A dynamic, innovative, and collaborative environment driven by a passion for scientific discovery and a commitment to translating research into impactful medicines. The culture emphasizes interdisciplinary teamwork, intellectual rigor, and a fast-paced startup mentality.

HQ Significance:

The Singapore HQ leverages the nation's strong government support for biotech, access to diverse talent, and its position as a gateway to Asia-Pacific markets and clinical research opportunities.

Values Reflected in HQ: Innovation, scientific excellence, collaboration, and a patient-centric approach to drug development are reflected in its location within a leading research hub and its focus on cutting-edge technologies.

Location:

Engine Biosciences operates with a significant presence in two key global biotech hubs: Singapore, serving as its R&D and corporate headquarters, and San Francisco, USA, facilitating its North American operations, partnerships, and clinical development. This dual footprint allows them to leverage diverse talent pools, research ecosystems, and strategic market access in both Asia-Pacific and North America.

Street Address:

3 Biopolis Drive, #04-11/12, Synapse

City:

Singapore

State/Province:

Country:

Singapore

Engine Biosciences's Global Presence

San Francisco, California, USA

Address: MBC BioLabs, 953 Indiana St, San Francisco, CA 94107, USA (Typical for biotech startups; specific suite may vary or be part of a shared lab space)

To engage with the extensive network of pharmaceutical companies, research institutions, clinical sites, and venture capital in one of the world's leading biotech clusters.

Buying Intent Signals for Engine Biosciences

Highperformr Signals uncover buying intent and give you clear insights to target the right accounts at the right time — helping your sales, marketing, and GTM teams close more deals, faster.

Notable news
Hiring actively
Corporate Finance
Corporate Finance
Corporate Finance
Corporate Finance
Corporate Finance
*Example signal, not calculated in real time

Executive Team of Engine Biosciences

As of April 2025, Engine Biosciences' leadership includes:

Jeffrey Lu - Co-Founder & Chief Executive Officer
Timothy K. Chua, Ph.D. - Co-Founder & Chief Operating Officer
Daryl S.L. Lim, Ph.D. - Co-Founder & Chief Technology Officer
David S.P. Tan, MBBS, Ph.D., FRCP - Senior Vice President, Translational Medicine
Dominik Wodarz, D.Phil - Head of Computational Biology

Investors of Engine Biosciences

Engine Biosciences has been backed by several prominent investors over the years, including:

Lightstone Ventures
Polaris Partners
ClavystBio (an SPH company)
EDBI (Economic Development Board Investments, Singapore)
DHVC (Digital Horizon Capital)
WuXi AppTec
Vectr Ventures
Baidu Ventures
6 Dimensions Capital
SEEDS Capital (Enterprise Singapore)

Executive New Hires/Exits in the Last 12 Months

Hire0
Exits0

Based on publicly available information, there have been no major, widely announced executive hires or departures at Engine Biosciences in the last 12-18 months. The core leadership team appears to have remained consistent, focusing on advancing their pipeline.

Technology (Tech Stack) used by Engine Biosciences

Discover the tools Engine Biosciences uses. Highperformr reveals the technologies powering your target accounts — helping your sales, marketing, and GTM teams prioritize smarter and close faster.

Engine Biosciences Email Formats and Examples

Engine Biosciences likely utilizes common corporate email formats. Based on industry standards and company size, the most probable format is [first_initial][last]@[companydomain].com or [first].[last]@[companydomain].com.

[first_initial][last]@enginebio.com

Format

jlu@enginebio.com

Example

80%

Success rate

News and media

Business WireMarch 19, 2024

Engine Biosciences Announces First Patient Dosed in Phase 1 Clinical Trial of ENB-201 for Solid Tumors with KRAS/TP53 Co-mutations

Engine Biosciences announced that the first patient has been dosed in its Phase 1 clinical trial of ENB-201, a targeted therapy for solid tumors characterized by KRAS/TP53 co-mutations. This marks a significant milestone in advancing their lead oncology program....more

PR NewswireJanuary 23, 2024

Engine Biosciences Receives FDA Fast Track Designation for ENB-201 for the Treatment of KRAS/TP53 Co-Mutated Solid Tumors

The U.S. Food and Drug Administration (FDA) granted Fast Track designation to Engine Biosciences' ENB-201 for the treatment of adult patients with KRAS/TP53 co-mutated solid tumors. This designation is intended to facilitate the development and expedite the review of drugs to treat serious conditions and fill an unmet medical need....more

BioSpaceSeptember 14, 2023

Engine Biosciences Presents Preclinical Data on ENB-201 Demonstrating Potent Anti-Tumor Activity in KRAS/TP53 Co-Mutated Cancers at AACR Special Conference

Engine Biosciences presented compelling preclinical data for its lead candidate, ENB-201, at the American Association for Cancer Research (AACR) Special Conference. The data showed significant anti-tumor activity in models of cancers with KRAS/TP53 co-mutations, a patient population with limited treatment options....more

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