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The Duke Clinical Research Institute (DCRI), part of Duke University School of Medicine, is the world's largest academic research organization (ARO). It uniquely combines the clinical expertise and academic leadership of a premier institution with the full-service operational capabilities of a contract research organization (CRO). DCRI is dedicated to developing and sharing knowledge that improves the care of patients globally through pioneering clinical research. Its scope encompasses a wide array of therapeutic areas, all phases of clinical trials, outcomes research, health services research, and patient safety initiatives.
Serves as the central operational and intellectual hub for DCRI's global clinical research activities, housing faculty, researchers, biostatisticians, data scientists, and administrative staff who design, manage, and analyze clinical trials and health studies.
State-of-the-art research facilities, advanced data analytics infrastructure, collaborative workspaces designed to foster interdisciplinary teamwork. The North Pavilion building is a key facility specifically developed for research entities within Duke Health.
A highly collaborative, intellectually stimulating, and mission-driven environment. Emphasizes scientific rigor, innovation, mentorship, and a commitment to improving patient health worldwide. Strong interdisciplinary teamwork is a hallmark.
As the nerve center for the world's largest ARO, the DCRI headquarters is instrumental in conducting landmark clinical trials that shape medical practice and health policy globally. Its co-location with Duke University and Duke Health fosters seamless translation of research into clinical care.
While headquartered in Durham, NC, the Duke Clinical Research Institute (DCRI) operates on a global scale, conducting and coordinating clinical trials and research studies in numerous countries across six continents. Its international footprint is established through a vast network of collaborating research sites, investigators, academic institutions, and healthcare systems worldwide. DCRI provides comprehensive global support for multinational studies, including study design, site identification and management, patient recruitment, global data collection and harmonization, regulatory expertise, and safety monitoring, all aimed at improving health outcomes for diverse populations around the world.
2400 Pratt Street (North Pavilion)
Durham
North Carolina
USA
Address: 200 Morris Street (Durham Centre), Durham, NC 27701
To provide flexible, modern office space for various research support functions, facilitating efficient project execution and collaboration among diverse teams, while being strategically located within the vibrant research community of Durham.
Address: 300 West Morgan Street (Durham ID), Durham, NC 27701
To integrate DCRI's data-intensive research arms within a hub of innovation, allowing for synergies with tech companies and startups, and to provide specialized environments for data analytics and computational research.
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As of April 2025, Duke Clinical Research Institute' leadership includes:
Duke Clinical Research Institute has been backed by several prominent investors over the years, including:
Specific executive hire and exit announcements for the Duke Clinical Research Institute are typically managed within the broader Duke University Health System or School of Medicine communications framework. Publicly available information on distinct DCRI executive team changes within the last 12 months is limited, often reflecting academic appointments or internal role shifts rather than corporate-style executive moves. DCRI generally maintains strong leadership continuity.
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Email addresses for individuals at the Duke Clinical Research Institute generally adhere to the standard email format used by Duke University and Duke Health. The most prevalent format is [first_name].[last_name]@duke.edu. Some variations might exist, such as using a middle initial or a slightly different convention for common names.
[first_name].[last_name]@duke.edu
Format
jane.doe@duke.edu
Example
90%
Success rate
dcri.org • April 29, 2024
The DCRI hosted the inaugural summit for the NIH's Artificial Intelligence/Machine Learning Consortium to Advance Health Equity and Researcher Diversity (AIM-AHEAD) program. The event brought together national experts to strategize on leveraging AI/ML to reduce health disparities and promote equity in healthcare research and application....more
Duke Today • April 7, 2024
A large-scale international clinical trial, TRANSFORM-HF, co-led by DCRI's Executive Director Dr. Adrian Hernandez, found that the diuretic torsemide was not superior to the older, less expensive furosemide in reducing deaths or hospitalizations for patients with heart failure. The findings were presented at the American College of Cardiology's Annual Scientific Session and published in JAMA....more
dcri.org • November 13, 2023
The results of the landmark ADAPTABLE aspirin study, a pragmatic trial coordinated by DCRI and funded by PCORI, were published in the New England Journal of Medicine. The study compared two different doses of aspirin for secondary prevention of cardiovascular events, providing crucial evidence for patient and clinician decision-making....more
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