CRF Health was a prominent global provider of electronic Clinical Outcome Assessment (eCOA) solutions for the pharmaceutical, biotech, and medical device industries, as well as Contract Research Organizations (CROs). Founded in 2000, the company focused on improving the quality, accuracy, and efficiency of clinical trials through patient-centric data collection technologies, including ePRO (electronic Patient Reported Outcomes), ClinRO (Clinician Reported Outcomes), and ObsRO (Observer Reported Outcomes). In 2018, CRF Health merged with Bracket, another leader in clinical trial technology and specialty services, backed by Genstar Capital. The combined entity was subsequently rebranded as Signant Health. CRF Health's expertise and technology in eCOA form a foundational part of Signant Health's comprehensive suite of solutions aimed at optimizing clinical research and patient engagement.
Serves as the central hub for Signant Health's global operations, strategic leadership, product innovation, corporate governance, and administrative functions.
Located in One Liberty Place, a landmark skyscraper in Center City Philadelphia, offering state-of-the-art facilities and a strategic position within a major business and life sciences hub.
The work culture at Signant Health, including the legacy of CRF Health, emphasizes innovation, patient centricity, scientific rigor, and collaboration to advance clinical research and improve trial outcomes. It fosters a dynamic environment focused on technology and service excellence.
The Philadelphia headquarters symbolizes the unification of CRF Health and Bracket into Signant Health, establishing a significant global leader in clinical trial technology solutions. It represents a central point for driving innovation and supporting complex global studies.
Signant Health operates globally, supporting clinical trials in numerous countries. Its worldwide infrastructure includes project management teams, data management specialists, logistics networks for device provisioning (e.g., for eCOA), software development centers, and 24/7 multilingual customer support for trial sites and patients. This global footprint enables Signant Health to provide localized expertise, navigate diverse regulatory environments, and ensure seamless execution of international clinical studies, building on CRF Health's pioneering work in global eCOA deployment.
One Liberty Place, 1650 Market Street, 30th Floor
Philadelphia
PA
USA
Address: The Triangle, 5-17 Hammersmith Grove, London, W6 0LG, UK
Serves as a strategic center for Signant Health's European operations, ensuring localized expertise and timely support for pharmaceutical companies, biotech firms, and CROs conducting trials in Europe, the Middle East, and Africa.
Address: Lars Sonckin kaari 12, 02600 Espoo, Finland
Functions as a significant technology and innovation hub, particularly for eCOA solutions, contributing to Signant Health's global product development and supporting clients in the Nordic and Baltic regions.
Address: Prestige Khoday Tower, No.5, Ground floor & 6th floor, Raj Bhavan Rd, Bengaluru, Karnataka 560001, India
Enhances Signant Health's global service delivery capabilities, provides scalability for operations, and supports innovation in clinical trial technologies for clients worldwide.
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As of April 2025, CRF Health' leadership includes:
CRF Health has been backed by several prominent investors over the years, including:
Signant Health has made strategic appointments to its executive team in the past 12-18 months to strengthen its operational and commercial leadership as it continues to grow its presence in the clinical trial technology market. Key hires include a Chief Operating Officer and a Chief Commercial Officer.
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Signant Health, the successor to CRF Health, commonly uses the 'first.last@signanthealth.com' email format. A less frequent alternative is '[first_initial][last]@signanthealth.com'. Understanding these patterns can be useful for professional communication.
first.last@signanthealth.com
Format
jane.doe@signanthealth.com
Example
85%
Success rate
Signant Health Press Release • May 21, 2024
Signant Health announced the addition of Korean language capabilities to its SmartSignals™ eCOA platform, expanding accessibility for clinical trials in Korea and enhancing patient-centric data collection globally....more
Signant Health Press Release • February 20, 2024
Signant Health has expanded its global operations by opening a new office in Bangalore, India, to enhance its service delivery, support innovation, and tap into the region's talent pool for clinical trial technology....more
Signant Health Press Release • January 23, 2024
Signant Health announced its patient-facing mobile application for clinical trials now conforms to Web Content Accessibility Guidelines (WCAG) 2.1 Level AA, ensuring greater accessibility for all trial participants....more
Signant Health Press Release • October 10, 2023
Signant Health announced the appointment of Andrew Witty as its new Chief Commercial Officer, tasked with driving the company's global commercial strategy and growth initiatives....more
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