Casebia Therapeutics was a biotechnology company established as a joint venture between CRISPR Therapeutics and Bayer, announced in December 2015 and commencing operations in 2016. Its mission was to discover, develop, and commercialize new CRISPR/Cas9-based therapies for genetic diseases, with initial focuses on blood disorders, blindness, and cardiovascular diseases. Headquartered in Cambridge, Massachusetts, Casebia aimed to combine CRISPR Therapeutics' gene editing technology with Bayer's protein engineering expertise and disease know-how. In May 2019, CRISPR Therapeutics acquired Bayer's stake in Casebia, fully integrating its operations, research programs, and intellectual property. While Casebia Therapeutics no longer operates as an independent entity, its foundational work contributed significantly to the advancement of gene editing therapies within CRISPR Therapeutics.
The headquarters served as the primary center for research and development, program management, and administrative operations for Casebia's gene editing initiatives, focusing on translating CRISPR/Cas9 technology into viable therapeutics.
Located in a modern biotech facility within Kendall Square, offering state-of-the-art laboratory spaces, advanced research equipment, and collaborative work environments designed to foster innovation.
As a cutting-edge research-focused biotech venture, the work culture at Casebia Therapeutics emphasized scientific excellence, innovation, rigorous collaboration, and a strong mission-driven approach to developing transformative treatments for severe genetic diseases.
The Cambridge headquarters was strategically significant due to its location in Kendall Square, providing access to world-class academic institutions (like MIT and Harvard), a rich talent pool, and a dense ecosystem of biotech companies, VCs, and research organizations, fostering collaboration and accelerating R&D.
During its operation as a joint venture, Casebia Therapeutics leveraged the global research, development, and clinical expertise of its parent companies, CRISPR Therapeutics (with operations in the US and Europe) and Bayer (a global pharmaceutical company). Casebia's direct operational footprint was primarily in the United States, with its headquarters and main research facility in Cambridge, MA, and a planned research presence in San Francisco, CA. Following its integration, its programs and intellectual property became part of CRISPR Therapeutics' global R&D pipeline and strategy.
100 Binney Street, Suite 600 (Primary operational address; also closely associated with CRISPR Therapeutics' facilities such as 610 Main Street)
Cambridge
Massachusetts
USA
Address: Specific address not publicly detailed; likely a dedicated research site or co-located within Bayer's West Coast facilities.
To tap into the strong biotechnology ecosystem of the San Francisco Bay Area, access specialized talent in protein engineering and preclinical development, and facilitate collaboration with Bayer's West Coast research infrastructure.
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As of April 2025, Casebia Therapeutics' leadership includes:
Casebia Therapeutics has been backed by several prominent investors over the years, including:
Casebia Therapeutics was fully integrated into CRISPR Therapeutics in mid-2019. Consequently, there have been no executive hires or exits specifically for Casebia Therapeutics as an independent entity in the last 12 months. Relevant news primarily pertains to its formation, key appointments during its operational period, or its integration.
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During its operational period (2016-2019), Casebia Therapeutics likely used a standard corporate email format. As the company was integrated into CRISPR Therapeutics and its domain (casebia.com) is no longer active for email, these formats are historical.
[first_initial][last]@casebia.com or [first].[last]@casebia.com
Format
jdoe@casebia.com or jane.doe@casebia.com
Example
5%
Success rate
CRISPR Therapeutics Press Release • May 30, 2019
CRISPR Therapeutics announced it has acquired Bayer’s 50% stake in their joint venture, Casebia Therapeutics. This transaction gives CRISPR Therapeutics full operational control and decision making for Casebia’s programs, intellectual property and team, which will be fully integrated into CRISPR Therapeutics....more
Business Wire (CRISPR Therapeutics) • December 21, 2015
CRISPR Therapeutics and Bayer AG today announced the launch of Casebia Therapeutics (Casebia), a joint venture (JV) to discover, develop and commercialize new breakthrough therapeutics to cure blood disorders, blindness, and congenital heart disease. Bayer will make a $300M equity investment in CRISPR Therapeutics. Bayer will provide a minimum of $335M to the JV over the next five years....more
CRISPR Therapeutics Press Release • April 12, 2016
Casebia Therapeutics, the joint venture founded by Bayer and CRISPR Therapeutics, today announced the appointment of James (Jim) W. Burns, Ph.D., as its President and Chief Executive Officer. Dr. Burns was formerly Head of Drug Discovery and Genzyme Sanofi and brings over 30 years of R&D leadership experience....more
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