Cain Brothers is a preeminent healthcare investment bank, operating as a division of KeyBanc Capital Markets (KBCM), the corporate and investment banking arm of KeyCorp. For over 40 years, Cain Brothers has been dedicated to providing comprehensive advisory and capital raising services exclusively to the healthcare industry. Their expertise encompasses mergers and acquisitions, capital markets (debt and equity), and strategic advisory across diverse healthcare sectors, including hospitals and health systems, physician practices, managed care, life sciences, medical technology, and healthcare IT. They leverage deep industry knowledge and extensive transaction experience to deliver tailored financial solutions and strategic guidance, helping clients navigate the complex and evolving healthcare landscape.
Serves as a primary center for healthcare investment banking advisory, M&A execution, and capital raising activities, connecting with clients and investors in a major global financial hub.
Located in a prominent Manhattan business district, offering modern office facilities and access to extensive financial industry infrastructure and talent.
Characterized by a fast-paced, results-driven environment typical of investment banking, with a strong emphasis on deep healthcare industry expertise, client service excellence, and collaborative teamwork.
The New York office is significant due to its location in a global financial epicenter, facilitating direct access to capital markets, institutional investors, and a high concentration of healthcare companies, innovations, and thought leaders.
Primarily focused on the U.S. healthcare market, Cain Brothers, as an integral part of KeyBanc Capital Markets, leverages KeyCorp's broader network and capabilities. Their deep expertise in the U.S. healthcare sector frequently involves cross-border transactions, advising domestic clients on international opportunities and international clients on U.S. market entry or investments. Their global reach for transaction execution and market intelligence is facilitated through KeyBanc Capital Markets' established relationships and platforms.
10 E. 53rd Street, 29th Floor
New York
NY
USA
Address: One Letterman Drive, Building C, Suite 410, San Francisco, CA 94129
Strategic presence to cater to the vibrant healthcare innovation ecosystem in California and the broader Pacific region, including venture-backed companies and established players.
Address: 10 S. Wacker Drive, Suite 3475, Chicago, IL 60606
Provides regional coverage and access to capital markets for healthcare organizations in a key commercial and transportation hub in the Midwest.
Address: 127 Public Square, Cleveland, OH 44114
Integral to KeyCorp's overall operations, providing synergistic support to Cain Brothers' specialized healthcare investment banking activities.
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As of April 2025, Cain Brothers' leadership includes:
Cain Brothers has been backed by several prominent investors over the years, including:
Cain Brothers, as part of KeyBanc Capital Markets' Healthcare group, has actively strengthened its team with strategic Managing Director hires in specialized areas such as healthcare leveraged finance and healthcare IT. No major public announcements of executive departures from the core Cain Brothers leadership team have been noted in the last 12 months.
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As Cain Brothers is a division of KeyBanc Capital Markets (which is part of KeyCorp), employees typically use KeyCorp's email domain (@key.com). The most common email format observed is the first initial of the first name followed by the full last name.
flastname@key.com (e.g., jsmith@key.com)
Format
rfraiman@key.com
Example
90%
Success rate
Business Wire • February 13, 2024
KeyBanc Capital Markets (KBCM), with its healthcare division Cain Brothers, announced it served as the exclusive financial advisor to NovaQuest Capital Management in connection with its strategic growth investment in Clinical ink, a global life science technology company providing eSource and patient engagement solutions....more
Business Wire • January 11, 2024
KeyBanc Capital Markets (KBCM), including its Cain Brothers division, acted as the exclusive sell-side M&A advisor to Unified Women’s Healthcare, a leading practice management platform in women’s healthcare, on its sale to Altas Partners and Caisse de dépôt et placement du Québec (CDPQ)....more
Business Wire • December 5, 2023
KeyBanc Capital Markets (KBCM), including its Cain Brothers division, announced it acted as Lead Arranger, Bookrunner, and Administrative Agent on senior secured credit facilities to support GTCR's acquisition of American Orthopedic Partners (AOP), a physician-owned orthopedic practice....more
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