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Cain Brothers's Overview

Total employees182
HeadquartersNew York
Founded1982

Cain Brothers is a preeminent healthcare investment bank, operating as a division of KeyBanc Capital Markets (KBCM), the corporate and investment banking arm of KeyCorp. For over 40 years, Cain Brothers has been dedicated to providing comprehensive advisory and capital raising services exclusively to the healthcare industry. Their expertise encompasses mergers and acquisitions, capital markets (debt and equity), and strategic advisory across diverse healthcare sectors, including hospitals and health systems, physician practices, managed care, life sciences, medical technology, and healthcare IT. They leverage deep industry knowledge and extensive transaction experience to deliver tailored financial solutions and strategic guidance, helping clients navigate the complex and evolving healthcare landscape.

Where is Cain Brothers's Headquarters?

HQ Function

Serves as a primary center for healthcare investment banking advisory, M&A execution, and capital raising activities, connecting with clients and investors in a major global financial hub.

Notable Features:

Located in a prominent Manhattan business district, offering modern office facilities and access to extensive financial industry infrastructure and talent.

Work Culture:

Characterized by a fast-paced, results-driven environment typical of investment banking, with a strong emphasis on deep healthcare industry expertise, client service excellence, and collaborative teamwork.

HQ Significance:

The New York office is significant due to its location in a global financial epicenter, facilitating direct access to capital markets, institutional investors, and a high concentration of healthcare companies, innovations, and thought leaders.

Values Reflected in HQ: The office environment reflects professionalism, deep market expertise, discretion, and a client-centric approach, fostering an atmosphere conducive to high-stakes financial advisory and strategic decision-making.

Location:

Primarily focused on the U.S. healthcare market, Cain Brothers, as an integral part of KeyBanc Capital Markets, leverages KeyCorp's broader network and capabilities. Their deep expertise in the U.S. healthcare sector frequently involves cross-border transactions, advising domestic clients on international opportunities and international clients on U.S. market entry or investments. Their global reach for transaction execution and market intelligence is facilitated through KeyBanc Capital Markets' established relationships and platforms.

Street Address:

10 E. 53rd Street, 29th Floor

City:

New York

State/Province:

NY

Country:

USA

Cain Brothers's Global Presence

San Francisco, CA/USA

Address: One Letterman Drive, Building C, Suite 410, San Francisco, CA 94129

Strategic presence to cater to the vibrant healthcare innovation ecosystem in California and the broader Pacific region, including venture-backed companies and established players.

Chicago, IL/USA

Address: 10 S. Wacker Drive, Suite 3475, Chicago, IL 60606

Provides regional coverage and access to capital markets for healthcare organizations in a key commercial and transportation hub in the Midwest.

Cleveland, OH/USA

Address: 127 Public Square, Cleveland, OH 44114

Integral to KeyCorp's overall operations, providing synergistic support to Cain Brothers' specialized healthcare investment banking activities.

Buying Intent Signals for Cain Brothers

Highperformr Signals uncover buying intent and give you clear insights to target the right accounts at the right time — helping your sales, marketing, and GTM teams close more deals, faster.

Notable news
Hiring actively
Corporate Finance
Corporate Finance
Corporate Finance
Corporate Finance
Corporate Finance
*Example signal, not calculated in real time

Executive Team of Cain Brothers

As of April 2025, Cain Brothers' leadership includes:

Robert J. Fraiman, Jr. - President, Cain Brothers and Co-Head, KeyBanc Capital Markets Healthcare Group
James A. Liddell - Managing Director and Head of Healthcare M&A
Zachary B. Kau - Managing Director and Head of Healthcare Public Finance
Michael L. Lunder - Managing Director and Head of Healthcare Capital Markets
John M. Sinnenberg - Managing Director and Chairman of Healthcare Public Finance

Investors of Cain Brothers

Cain Brothers has been backed by several prominent investors over the years, including:

KeyCorp

Executive New Hires/Exits in the Last 12 Months

Hire2
Exits0

Cain Brothers, as part of KeyBanc Capital Markets' Healthcare group, has actively strengthened its team with strategic Managing Director hires in specialized areas such as healthcare leveraged finance and healthcare IT. No major public announcements of executive departures from the core Cain Brothers leadership team have been noted in the last 12 months.

New Appointments:

John S. Poelker, John S. Poelker appointed as Managing Director, Head of Healthcare Leveraged Finance within KeyBanc Capital Markets' Healthcare Group.
Brian P. Regan, Brian P. Regan appointed as Managing Director in KeyBanc Capital Markets' Healthcare Group, specializing in Healthcare Information Technology.

Technology (Tech Stack) used by Cain Brothers

Discover the tools Cain Brothers uses. Highperformr reveals the technologies powering your target accounts — helping your sales, marketing, and GTM teams prioritize smarter and close faster.

Cain Brothers Email Formats and Examples

As Cain Brothers is a division of KeyBanc Capital Markets (which is part of KeyCorp), employees typically use KeyCorp's email domain (@key.com). The most common email format observed is the first initial of the first name followed by the full last name.

flastname@key.com (e.g., jsmith@key.com)

Format

rfraiman@key.com

Example

90%

Success rate

News and media

Business WireFebruary 13, 2024

Cain Brothers (as part of KeyBanc Capital Markets) Advises NovaQuest on Investment in Clinical ink

KeyBanc Capital Markets (KBCM), with its healthcare division Cain Brothers, announced it served as the exclusive financial advisor to NovaQuest Capital Management in connection with its strategic growth investment in Clinical ink, a global life science technology company providing eSource and patient engagement solutions....more

Business WireJanuary 11, 2024

Cain Brothers (as part of KeyBanc Capital Markets) Advises Unified Women’s Healthcare on Sale

KeyBanc Capital Markets (KBCM), including its Cain Brothers division, acted as the exclusive sell-side M&A advisor to Unified Women’s Healthcare, a leading practice management platform in women’s healthcare, on its sale to Altas Partners and Caisse de dépôt et placement du Québec (CDPQ)....more

Business WireDecember 5, 2023

Cain Brothers (as part of KeyBanc Capital Markets) Announces Financing for American Orthopedic Partners Acquisition

KeyBanc Capital Markets (KBCM), including its Cain Brothers division, announced it acted as Lead Arranger, Bookrunner, and Administrative Agent on senior secured credit facilities to support GTCR's acquisition of American Orthopedic Partners (AOP), a physician-owned orthopedic practice....more

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