AvroBio, Inc. was a clinical-stage gene therapy company dedicated to developing potentially curative lentiviral-based gene therapies to treat rare diseases. Their investigational therapies involved genetically modifying a patient's own hematopoietic stem cells (HSCs) to produce functional proteins, aiming to address the underlying cause of diseases such as cystinosis, Fabry disease, Gaucher disease type 1, and Pompe disease. In December 2023, Novartis announced an agreement to acquire AvroBio, a transaction completed in February 2024. AvroBio's programs, particularly its investigational HSC gene therapy for cystinosis (AVR-RD-04), and expertise have been integrated into Novartis's gene therapy portfolio.
Served as the central hub for corporate administration, research and development leadership, clinical operations, and strategic planning for AvroBio's gene therapy programs.
The headquarters housed state-of-the-art laboratory facilities for cell processing, analytical development, and translational research. Its location in Kendall Square provided proximity to leading academic institutions, research organizations, and other biotech companies.
AvroBio's work culture was characterized by a patient-centric, science-driven, and collaborative environment. Employees were passionate about advancing gene therapies for rare diseases, working in a dynamic and innovative setting.
The Cambridge HQ was pivotal for AvroBio, offering access to a rich talent pool, cutting-edge research collaborations (e.g., with MIT and Harvard affiliates), and a strong venture capital and biopharma network, all essential for a developing gene therapy company.
While headquartered in Cambridge, MA, USA, AVROBIO had a global operational footprint. Its clinical trials for various gene therapies were conducted across multiple countries in North America, Europe, and Australia to reach diverse patient populations. The company also had early research and development operations in Toronto, Canada, and established a dedicated cGMP viral vector manufacturing facility in Durham, North Carolina, USA, to support its clinical programs worldwide.
One Kendall Square, Building 300, Suite 201
Cambridge
MA
USA
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As of April 2025, AVROBIO' leadership includes:
AVROBIO has been backed by several prominent investors over the years, including:
The acquisition of AVROBIO by Novartis, completed in February 2024, led to the departure of AVROBIO's executive team as a standalone entity. Key leadership roles were either integrated into Novartis or made redundant as operations were consolidated. Most executive changes in the preceding 12-18 months were linked to strategic shifts leading up to or resulting from this acquisition.
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Prior to its acquisition by Novartis, AVROBIO, Inc. likely utilized standard corporate email address formats. Common patterns included the first initial followed by the last name, or the full first name separated by a period from the last name, all preceding '@avrobio.com'. These email addresses are no longer active.
[first_initial][last]@avrobio.com (e.g., jdoe@avrobio.com) OR [first].[last]@avrobio.com (e.g., jane.doe@avrobio.com)
Format
g Mackay@avrobio.com (example for Geoff MacKay using first initial last name format)
Example
70%
Success rate
Novartis Official Website • February 28, 2024
Novartis announced it has successfully completed the acquisition of AVROBIO, Inc. This strategic move aims to enhance Novartis's gene therapy capabilities, notably by incorporating AVROBIO's investigational hematopoietic stem cell (HSC) gene therapy for cystinosis, AVR-RD-04. The acquisition was valued at approximately USD 87.5 million....more
AVROBIO, Inc. / GlobeNewswire • December 19, 2023
AVROBIO, Inc. announced that it has entered into a definitive agreement under which Novartis will acquire AVROBIO for $3.00 per share in cash, representing an equity value of approximately $87.5 million. The transaction was unanimously approved by AVROBIO’s Board of Directors....more
AVROBIO, Inc. / GlobeNewswire • May 9, 2023
AVROBIO, Inc. announced a strategic reprioritization to concentrate its resources on advancing AVR-RD-04, its investigational hematopoietic stem cell (HSC) gene therapy program for cystinosis. As part of this, the company decided to discontinue direct investment in its Fabry disease, Gaucher disease type 1, and Pompe disease programs....more
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