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Aileron Therapeutics's Overview

Total employees11
HeadquartersCambridge
Founded2001

Aileron Therapeutics was a clinical-stage biopharmaceutical company that historically focused on developing and advancing a proprietary platform of 'stapled' alpha-helical peptides. These were designed to mimic the structures of natural proteins to modulate cellular pathways, primarily aimed at treating cancer and other serious diseases. Their lead drug candidate was ALRN-6924, which targeted the p53 tumor suppressor pathway. In late 2023, Aileron Therapeutics entered into a merger agreement with Lung Therapeutics, Inc., and the combined entity subsequently merged with Longeveron Inc. in early 2024, ceasing operations under the Aileron Therapeutics name.

Where is Aileron Therapeutics's Headquarters?

HQ Function

The Cambridge headquarters served as the command center for Aileron's corporate strategy, clinical development programs, research initiatives, and administrative operations.

Notable Features:

Located within a multi-tenant building in a key biotech cluster, the facility would have included modern office spaces designed to support executive, clinical, and administrative functions. Specific architectural highlights of their leased space are not publicly detailed.

Work Culture:

The work culture at Aileron Therapeutics, typical of a clinical-stage biotech, likely fostered innovation, scientific excellence, a strong sense of urgency, and collaboration, driven by the goal of addressing unmet medical needs for patients.

HQ Significance:

Its Cambridge location provided Aileron with strategic advantages, including proximity to leading academic institutions, a rich talent pool, and a vibrant ecosystem of research organizations and potential partners.

Values Reflected in HQ: The choice of a Cambridge HQ reflected Aileron's commitment to being at the forefront of scientific innovation and leveraging the resources of a leading biotech ecosystem to advance its therapeutic programs.

Location:

As a U.S.-based company, Aileron Therapeutics's global functions were primarily related to the execution of its clinical trials, which often involve international sites and collaborations with research institutions or contract research organizations (CROs) in various countries to access diverse patient populations and expertise.

Street Address:

840 Memorial Drive, Third Floor

City:

Cambridge

State/Province:

MA

Country:

USA

Aileron Therapeutics's Global Presence

Buying Intent Signals for Aileron Therapeutics

Highperformr Signals uncover buying intent and give you clear insights to target the right accounts at the right time — helping your sales, marketing, and GTM teams close more deals, faster.

Notable news
Hiring actively
Corporate Finance
Corporate Finance
Corporate Finance
Corporate Finance
Corporate Finance
*Example signal, not calculated in real time

Executive Team of Aileron Therapeutics

As of April 2025, Aileron Therapeutics' leadership includes:

Manuel C. Aivado, M.D., Ph.D. - Former President and Chief Executive Officer
Susan M. Dube, CPA - Former Chief Financial Officer and Secretary

Investors of Aileron Therapeutics

Aileron Therapeutics has been backed by several prominent investors over the years, including:

Apple Tree Partners
SR One
Lilly Ventures
Novartis Venture Funds
Roche Venture Fund
Excelestar Ventures
AJU IB Investment
Various public market institutional investors (post-IPO)

Executive New Hires/Exits in the Last 12 Months

Hire1
Exits2

In the 12 months leading up to its merger announcements, Aileron Therapeutics had a key executive appointment. The subsequent merger process led to the transition of its executive team as the company integrated into new entities.

Departures

Manuel C. Aivado, M.D., Ph.D., Role concluded as Aileron Therapeutics ceased to exist as an independent entity post-mergers.
Susan M. Dube, CPA, Role concluded as Aileron Therapeutics ceased to exist as an independent entity post-mergers.

New Appointments:

Susan M. Dube, CPA, Susan M. Dube was appointed as Chief Financial Officer and Secretary of Aileron Therapeutics.

Technology (Tech Stack) used by Aileron Therapeutics

Discover the tools Aileron Therapeutics uses. Highperformr reveals the technologies powering your target accounts — helping your sales, marketing, and GTM teams prioritize smarter and close faster.

Aileron Therapeutics Email Formats and Examples

Historically, Aileron Therapeutics used common corporate email formats. The primary domain associated with the company was aileronrx.com. Given the company's merger and cessation of operations under this name, these email addresses are no longer active.

Aileron Therapeutics likely used formats such as [first_initial][last]@aileronrx.com or [first].[last]@aileronrx.com

Format

jdoe@aileronrx.com

Example

0%

Success rate

News and media

GlobeNewswireOctober 24, 2023

Aileron Therapeutics and Lung Therapeutics Announce Definitive Merger Agreement

Aileron Therapeutics, Inc. and Lung Therapeutics, Inc. announced they entered into a definitive merger agreement to combine the companies in an all-stock transaction. The merged company planned to focus on advancing Lung Therapeutics' pipeline for rare lung diseases....more

GlobeNewswireJune 5, 2023

Aileron Therapeutics Announces 1-for-20 Reverse Stock Split

Aileron Therapeutics announced it would effect a 1-for-20 reverse stock split of its common stock, effective June 6, 2023, to regain compliance with Nasdaq's minimum bid price requirement....more

GlobeNewswireMarch 27, 2023

Aileron Therapeutics Appoints Susan M. Dube as Chief Financial Officer

Aileron Therapeutics announced the appointment of Susan M. Dube, CPA, as its Chief Financial Officer and Secretary. Ms. Dube brought over 20 years of finance and accounting experience in the life sciences industry to the role....more

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