.406 Ventures
.406 Ventures's Overview
.406 Ventures is an early-stage venture capital firm dedicated to investing in and supporting innovative enterprise technology and services companies. With a focus on sectors such as cybersecurity, data & analytics, digital health, and cloud infrastructure, .406 Ventures partners with visionary entrepreneurs to build market-leading businesses. The firm provides not only capital but also deep operational expertise and an extensive network to help its portfolio companies achieve significant growth and success. They typically lead or co-lead Seed and Series A funding rounds.
Where is .406 Ventures's Headquarters?
HQ Function
The Boston headquarters serves as the central hub for .406 Ventures' investment activities, including deal sourcing, due diligence, portfolio company management, and operations. It's where strategic decisions are made and collaborations with entrepreneurs are fostered.
Notable Features:
Located in the Financial District, offering a professional and collaborative workspace designed to facilitate interaction between partners, entrepreneurs, and industry experts. The office provides modern amenities conducive to a high-performance venture capital environment.
Work Culture:
The work culture at .406 Ventures is characterized by a deep commitment to collaboration, intellectual curiosity, and a hands-on approach to supporting portfolio companies. It's an environment where experienced investors work closely with founders, emphasizing partnership and long-term value creation.
HQ Significance:
The Boston headquarters is strategically located in a major innovation hub, providing .406 Ventures with direct access to a rich ecosystem of startups, research institutions, and talent, particularly in enterprise technology and healthcare sectors.
Values Reflected in HQ: The headquarters reflects values of professionalism, accessibility, and a focus on fostering strong relationships. The choice of location underscores their commitment to being at the center of technological innovation and entrepreneurial activity.
Location:
.406 Ventures primarily focuses its investments in early-stage companies located in North America, with a strong emphasis on the East Coast of the United States. While their direct investment footprint is concentrated, many of their portfolio companies have global operations or ambitions. .406 Ventures supports this international expansion through strategic advice, network connections, and by co-investing with firms that have a global reach. Their global presence is thus more indirect, reflected in the international activities of the companies they back.
Street Address:
60 South Street, Suite 950, Two Financial Center
City:
Boston
State/Province:
MA
Country:
USA
.406 Ventures's Global Presence
N/A - Primarily Operates from Boston HQ
Address: Not Applicable
The firm's model focuses on a strong central hub for core activities, leveraging partner networks across various regions rather than establishing multiple physical offices.
Buying Intent Signals for .406 Ventures
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Executive Team of .406 Ventures
As of April 2025, .406 Ventures' leadership includes:
Investors of .406 Ventures
.406 Ventures has been backed by several prominent investors over the years, including:
Executive New Hires/Exits in the Last 12 Months
Based on publicly available information as of mid-2024, .406 Ventures has not announced major executive hires or departures within the core partnership team in the last 12 months. The firm appears to maintain a stable leadership structure, focusing on its investment activities.
Technology (Tech Stack) used by .406 Ventures
Discover the tools .406 Ventures uses. Highperformr reveals the technologies powering your target accounts — helping your sales, marketing, and GTM teams prioritize smarter and close faster.
.406 Ventures Email Formats and Examples
.406 Ventures commonly uses the email format combining an employee's first initial and last name. This is a typical pattern for many venture capital and professional services firms.
[first_initial][last]@406ventures.com
Format
ldonohue@406ventures.com
Example
90%
Success rate
News and media
Business Wire • May 8, 2024
.406 Ventures Portfolio Company ChaosSearch Raises $70 Million in Growth Financing
ChaosSearch, a data lake platform company and a portfolio investment of .406 Ventures, has secured $70 million in growth financing. .406 Ventures participated in the round, underscoring its continued commitment to supporting its innovative portfolio companies....more
PR Newswire • April 9, 2024
.406 Ventures Leads $4.5M Seed Funding for Cybersecurity Startup Ofense
Cybersecurity startup Ofense announced it has raised $4.5 million in a seed funding round led by .406 Ventures. This investment will fuel Ofense's development of a novel platform aimed at enabling security teams to proactively address and neutralize cyber threats....more
PR Newswire • January 24, 2023
.406 Ventures Closes Fifth Fund at $294 Million
.406 Ventures announced the successful closing of its fifth fund, .406 Ventures V, L.P., with $294 million in capital commitments. This fund will enable the firm to continue its strategy of investing in early-stage enterprise technology companies across key sectors like cybersecurity, data/analytics, digital health, and vertical SaaS....more
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